{"id":89600,"date":"2026-08-03T10:17:05","date_gmt":"2026-08-03T02:17:05","guid":{"rendered":"https:\/\/www.wsisp.com\/helps\/89600.html"},"modified":"2026-08-03T10:17:05","modified_gmt":"2026-08-03T02:17:05","slug":"5291%e4%bb%bd%e6%a0%b7%e6%9c%ac%ef%bc%81%e5%9b%a0%e6%9e%9c%e6%8e%a8%e6%96%ad%e5%a4%9a%e7%bb%84%e5%ad%a6","status":"publish","type":"post","link":"https:\/\/www.wsisp.com\/helps\/89600.html","title":{"rendered":"5,291\u4efd\u6837\u672c\uff01\u56e0\u679c\u63a8\u65ad\u591a\u7ec4\u5b66"},"content":{"rendered":"<h4 style=\"margin-left:0;margin-right:0\">\u8981\u70b9<\/h4>\n<p style=\"margin-left:0;margin-right:0\"><span style=\"color:#47c1a8\">\u5df2\u77e5&#xff1f;<\/span><\/p>\n<ul>\n<li>\n<p style=\"margin-left:0;margin-right:0\">\u5404\u7c7b\u6fc0\u9176\u6291\u5236\u5242\u5747\u666e\u904d\u5b58\u5728\u5fc3\u810f\u6bd2\u6027\u3002<\/p>\n<\/li>\n<li>\n<p style=\"margin-left:0;margin-right:0\">\u73b0\u6709\u673a\u5236\u7814\u7a76\u4ec5\u80fd\u53d1\u73b0\u76f8\u5173\u6027&#xff0c;\u96be\u4ee5\u8bc1\u5b9e\u56e0\u679c\u5173\u7cfb\u3002<\/p>\n<\/li>\n<\/ul>\n<p style=\"margin-left:0;margin-right:0\"><span style=\"color:#47c1a8\">\u65b0\u589e&#xff1f;<\/span><\/p>\n<ul>\n<li>\n<p style=\"margin-left:0;margin-right:0\">\u8bc1\u5b9e\u6709\u4e1d\u5206\u88c2\u901a\u8def\u7d0a\u4e71\u662f\u6fc0\u9176\u6291\u5236\u5242\u8bf1\u53d1\u5fc3\u810f\u6bd2\u6027\u7684\u6838\u5fc3\u5171\u6709\u673a\u5236\u3002<\/p>\n<\/li>\n<li>\n<p style=\"margin-left:0;margin-right:0\">\u6316\u6398\u51fa26\u7ec4\u7ecf\u9057\u4f20\u5b66\u8bc1\u636e\u9a8c\u8bc1\u7684\u6fc0\u9176\u4e0e\u5fc3\u8840\u7ba1\u75be\u75c5\u98ce\u9669\u56e0\u679c\u5173\u8054\u3002<\/p>\n<\/li>\n<\/ul>\n<p style=\"margin-left:0;margin-right:0\"><span style=\"color:#47c1a8\">\u4e34\u5e8a\u610f\u4e49&#xff1f;<\/span><\/p>\n<ul>\n<li>\n<p style=\"margin-left:0;margin-right:0\">\u4e3a\u672c\u9886\u57df\u63d0\u4f9b\u5206\u6790\u5de5\u5177&#xff0c;\u7528\u4e8e\u5fc3\u810f\u6bd2\u6027\u98ce\u9669\u9884\u5224\u4e0e\u76d1\u6d4b\u3002<\/p>\n<\/li>\n<li>\n<p style=\"margin-left:0;margin-right:0\">\u52a9\u529b\u7814\u53d1\u9002\u914d\u6fc0\u9176\u6291\u5236\u5242\u6cbb\u7597\u7684\u9776\u5411\u5fc3\u810f\u4fdd\u62a4\u65b9\u6848\u3002<\/p>\n<\/li>\n<\/ul>\n<p style=\"margin-left:0;margin-right:0\">dr.jian.zhang.phd&#064;gmail.com<\/p>\n<p style=\"margin-left:0;margin-right:0\">zhangj323&#064;mail.sysu.edu.cn<\/p>\n<p style=\"margin-left:0;margin-right:0\">linjijin&#064;gdph.org.cn<\/p>\n<p style=\"margin-left:0;margin-right:0\">#\u5fc3\u810f\u6bd2\u6027\u00a0#\u836f\u7269\u6bd2\u6027\u00a0#\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u00a0#\u8f6c\u5f55\u7ec4\u835f\u8403\u5206\u6790\u00a0#\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242<\/p>\n<h4 style=\"margin-left:0;margin-right:0\">\u80cc\u666f<\/h4>\n<p style=\"margin-left:0;margin-right:0\"><span style=\"color:#47c1a8\">\u6fc0\u9176\u6291\u5236\u5242&#xff08;KI&#xff09;<\/span>\u662f\u80bf\u7624\u9776\u5411\u6cbb\u7597\u6838\u5fc3\u836f\u7269&#xff0c;\u4f46\u5e38\u8bf1\u53d1\u5fc3\u810f\u6bd2\u6027&#xff0c;\u9650\u5236\u4e34\u5e8a\u5e94\u7528&#xff0c;\u4e9f\u9700\u7cfb\u7edf\u8d44\u6e90\u6316\u6398\u5176\u5185\u5728\u56e0\u679c\u673a\u5236\u3002<\/p>\n<h4 style=\"margin-left:0;margin-right:0\">\u65b9\u6cd5<\/h4>\n<p style=\"margin-left:0;margin-right:0\">\u672c\u7814\u7a76\u6784\u5efa<span style=\"color:#47c1a8\">\u6fc0\u9176\u6291\u5236\u5242\u5fc3\u810f\u6bd2\u6027\u6570\u636e\u5e93KICDB<\/span>&#xff0c;\u6574\u5408\u8f6c\u5f55\u7ec4\u835f\u8403\u5206\u6790\u4e0e\u56e0\u679c\u63a8\u65ad\u7684\u4ea4\u4e92\u5f0f\u7f51\u9875\u5e73\u53f0&#xff0c;\u7528\u4e8e\u8bc6\u522b\u6fc0\u9176\u6291\u5236\u5242\u5fc3\u810f\u6bd2\u6027\u5206\u5b50\u51b3\u5b9a\u56e0\u5b50\u3002<\/p>\n<p style=\"margin-left:0;margin-right:0\"><span style=\"color:#47c1a8\">\u529f\u80fd\u8fde\u901a\u6027\u5206\u6790\u4e0e\u6570\u636e\u5e93\u642d\u5efa<\/span><\/p>\n<\/p>\n<p class=\"img-center\"><img loading=\"lazy\" decoding=\"async\" alt=\"\u56fe\u7247\" class=\"rich_pages wxw-img\" height=\"1209\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/08\/20260803021701-6a6ffa1d18bec.png\" width=\"1080\" \/><\/p>\n<p style=\"margin-left:0;margin-right:0\">\u56fe1\u00a0\u00a0\u6574\u4f53\u7814\u7a76\u8bbe\u8ba1\u4e0eKICDB\u7f51\u9875\u754c\u9762<\/p>\n<p style=\"margin-left:0;margin-right:0\">(a) \u5b8c\u6574\u5206\u6790\u6d41\u7a0b\u793a\u610f\u56fe\u6570\u636e\u6e90&#xff1a;7\u5957\u4ebaiPSC\u5fc3\u808c\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6570\u636e\u96c6&#xff08;5,291\u6837\u672c&#xff09;\u300126\u6b3eFDA\u83b7\u6279\u6fc0\u9176\u6291\u5236\u5242&#xff1b;GWAS\u6570\u636e\u542b43\u79cd\u6fc0\u9176pQTL\/eQTL\u300146\u7c7b\u5fc3\u8840\u7ba1\u75be\u75c5\u8868\u578b\u3002\u5206\u6790\u6a21\u5757&#xff1a;\u8f6c\u5f55\u7ec4\u835f\u8403\u5206\u6790&#xff08;DESeq2 &#043;\u968f\u673a\u6548\u5e94\u6a21\u578b&#xff0c;\u5f97\u52308,907\u4e2a\u663e\u8457\u5dee\u5f02\u57fa\u56e0&#xff09;\u3001\u529f\u80fd\u8fde\u901a\u5206\u6790&#xff08;GSEA &#043;\u65af\u76ae\u5c14\u66fc\u76f8\u5173\u836f\u7269\u4e92\u4f5c\u7f51\u7edc&#xff09;\u3001\u53cc\u6837\u672c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316&#xff08;IVW\/MR-Egger\u7b49\u65b9\u6cd5&#xff0c;\u9274\u5b9a26\u7ec4\u663e\u8457\u56e0\u679c\u5173\u8054&#xff09;&#xff1b;\u6700\u7ec8\u6574\u5408\u4e3aKICDB\u673a\u5236\u89e3\u6790\u6d41\u7a0b\u3002<\/p>\n<p style=\"margin-left:0;margin-right:0\">(b) KICDB\u6570\u636e\u5e93\u9996\u9875\u622a\u56fe&#xff0c;\u5de6\u4fa7\u5bfc\u822a\u680f\u542b\u6d4f\u89c8\u3001\u835f\u8403\u5206\u6790\u3001\u56e0\u679c\u63a8\u65ad\u3001\u901a\u8def\u63a2\u7d22\u3001\u6570\u636e\u96c6\u5bf9\u6bd4\u3001\u4e0b\u8f7d\u3001\u5f15\u75287\u5927\u529f\u80fd\u6a21\u5757&#xff1b;\u9996\u9875\u5c55\u793a\u5206\u6790\u836f\u7269\u6570\u91cf\u3001\u7eb3\u5165\u7814\u7a76\u6570\u3001\u663e\u8457\u8f6c\u5f55\u7ec4\u6761\u76ee3\u9879\u6838\u5fc3\u7edf\u8ba1\u3002<\/p>\n<h4 style=\"margin-left:0;margin-right:0\">\u7ed3\u679c<\/h4>\n<p style=\"margin-left:0;margin-right:0\"><span style=\"color:#47c1a8\"><span style=\"color:#000000\">\u57fa\u4e8e5,291\u4efd\u6837\u672c\u7684\u835f\u8403\u5206\u6790\u8bc1\u5b9e&#xff1a;\u7834\u574f\u7ec6\u80de\u6709\u4e1d\u5206\u88c2&#xff08;\u67d3\u8272\u4f53\u5206\u79bb\u3001\u7ec6\u80de\u6838\u5206\u88c2&#xff09;\u662f\u5404\u7c7b\u6fc0\u9176\u6291\u5236\u5242\u5171\u6709\u7684\u6bd2\u6027\u673a\u5236&#xff1b;\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5206\u6790\u7b5b\u9009\u51fa26\u7ec4\u53ef\u9760\u56e0\u679c\u5173\u8054&#xff1a;RNF13\u3001TIE1\u7b49\u57fa\u56e0\u9057\u4f20\u8868\u8fbe\u5347\u9ad8\u4f1a\u63d0\u5347\u5fc3\u808c\u75c5\u3001\u5fc3\u6897\u53d1\u75c5\u98ce\u9669&#xff0c;TYRO3\u3001JAK2\u5219\u5177\u5907\u5fc3\u810f\u4fdd\u62a4\u6f5c\u529b\u3002<\/span><\/span><\/p>\n<p style=\"margin-left:0;margin-right:0\"><span style=\"color:#47c1a8\">\u7cfb\u7edf\u8f6c\u5f55\u7ec4\u835f\u8403\u5206\u6790\u63ed\u793a\u6fc0\u9176\u6291\u5236\u5242\u5171\u6709\u5fc3\u810f\u6bd2\u6027\u5206\u5b50\u7279\u5f81<\/span><\/p>\n<\/p>\n<p class=\"img-center\"><img loading=\"lazy\" decoding=\"async\" alt=\"\u56fe\u7247\" class=\"rich_pages wxw-img\" height=\"864\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/08\/20260803021701-6a6ffa1db34a7.png\" width=\"1080\" \/><\/p>\n<\/p>\n<p class=\"img-center\"><img loading=\"lazy\" decoding=\"async\" alt=\"\u56fe\u7247\" class=\"rich_pages wxw-img\" height=\"955\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/08\/20260803021702-6a6ffa1e257c7.png\" width=\"1080\" \/><\/p>\n<\/p>\n<p class=\"img-center\"><img loading=\"lazy\" decoding=\"async\" alt=\"\u56fe\u7247\" class=\"rich_pages wxw-img\" height=\"1079\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/08\/20260803021702-6a6ffa1e9d9e2.png\" width=\"1080\" \/><\/p>\n<p style=\"margin-left:0;margin-right:0\">\u56fe2\u00a0\u00a0\u6fc0\u9176\u6291\u5236\u5242\u8f6c\u5f55\u7ec4\u5dee\u5f02\u56fe\u8c31<\/p>\n<p style=\"margin-left:0;margin-right:0\">(a)\u00a0\u5384\u6d1b\u66ff\u5c3c\u3001\u62c9\u5e15\u66ff\u5c3c\u3001\u7d22\u62c9\u975e\u5c3c\u3001\u8212\u5c3c\u66ff\u5c3c\u835f\u8403\u5206\u6790\u706b\u5c71\u56fe&#xff1b;\u6bcf\u4e2a\u70b9\u4ee3\u8868\u5355\u4e2a\u57fa\u56e0&#xff0c;\u7ea2\u70b9\u663e\u8457\u4e0a\u8c03\u3001\u84dd\u70b9\u663e\u8457\u4e0b\u8c03&#xff08;FDR&lt;0.05&#xff09;&#xff0c;\u6807\u6ce8\u5dee\u5f02\u6700\u663e\u8457\u57fa\u56e0&#xff1b;\u5176\u4f59\u836f\u7269\u706b\u5c71\u56fe\u5b58\u653e\u4e8eKICDB\u6570\u636e\u5e93\u3002<\/p>\n<p style=\"margin-left:0;margin-right:0\">(b) 26\u79cd\u6fc0\u9176\u6291\u5236\u5242log2\u8868\u8fbe\u53d8\u5316\u65af\u76ae\u5c14\u66fc\u76f8\u5173\u805a\u7c7b\u70ed\u56fe&#xff0c;\u805a\u7c7b\u533a\u5206\u673a\u5236\u76f8\u8fd1\u836f\u7269\u7ec4\u3002<\/p>\n<p style=\"margin-left:0;margin-right:0\">(c) 26\u79cd\u6fc0\u9176\u6291\u5236\u5242\u5dee\u5f02\u57fa\u56e0\u5206\u5c42\u805a\u7c7b\u70ed\u56fe&#xff1b;\u4e0a\u65b9\u6ce8\u91ca&#xff1a;7\u5927\u7c7b\u6fc0\u9176\u6291\u5236\u5242&#xff08;\u7ea2&#061; EGFR\/ErbB\u3001\u84dd&#061; BCR-Abl\u3001\u7eff&#061; VEGFR\u591a\u6fc0\u9176\u3001\u7d2b&#061; ALK\/ROS1\u3001\u6a59&#061; BRAF\/MEK\u3001\u9ec4&#061; JAK\u3001\u68d5&#061; BTK&#xff09;&#xff1b;\u884c\u805a\u7c7b\u5206\u4e3a5\u5927\u529f\u80fd\u6a21\u5757&#xff1a;\u6a21\u57571\u6b21\u7ea7\u9187\u4ee3\u8c22\u3001\u6a21\u57572\u80f6\u8d28\u7ec6\u80de\u8fc1\u79fb\u3001\u6a21\u57573\u808c\u8089\u7cfb\u7edf\u8fdb\u7a0b\u3001\u6a21\u5757 4 \u80de\u5916\u57fa\u8d28\u7ec4\u88c5\u3001\u6a21\u57575\u67d3\u8272\u4f53\u5206\u79bb&#xff1b;\u989c\u8272\u4ee3\u8868log2\u500d\u6570\u53d8\u5316&#xff08;\u7ea2\u4e0a\u8c03&#xff0c;\u84dd\u4e0b\u8c03&#xff09;\u3002<\/p>\n<p style=\"margin-left:0;margin-right:0\"><span style=\"color:#47c1a8\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u8bc1\u5b9e\u6fc0\u9176\u76f8\u5173\u57fa\u56e0\u4e0e\u5fc3\u8840\u7ba1\u75be\u75c5\u56e0\u679c\u5173\u8054<\/span><\/p>\n<p style=\"margin-left:0;margin-right:0\">\u88681\u00a0\u00a0\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u56e0\u679c\u6548\u5e94\u7edf\u8ba1\u7ed3\u679c<\/p>\n<p style=\"margin-left:0;margin-right:0\">\u6fc0\u9176\u76f8\u5173\u57fa\u56e0\u66b4\u9732\u5bf9\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u56e0\u679c\u4f30\u7b97\u503c\u6c47\u603b<\/p>\n<p style=\"margin-left:0;margin-right:0\">\u5206\u4e3a\u836f\u7269\u57fa\u56e0MR\u3001\u6fc0\u9176MR\u4e24\u5927\u677f\u5757&#xff1b;\u5217&#xff1a;\u66b4\u9732\u5206\u5b50\u3001\u75be\u75c5\u7ed3\u5c40\u3001\u5de5\u5177SNP\u6570\u91cf\u3001\u6bd4\u503c\u6bd4OR&#xff08;95%\u7f6e\u4fe1\u533a\u95f4&#xff09;\u3001P\u503c\u3001FDR\u3001\u5f02\u8d28\u6027P&#xff1b;\u5168\u90e8\u5206\u6790\u91c7\u7528\u9006\u65b9\u5dee\u52a0\u6743\u6cd5&#xff0c;\u4ec5\u5c55\u793a\u663e\u8457\u5173\u8054\u7ed3\u679c&#xff1b;IV &#061;\u5de5\u5177\u53d8\u91cf&#xff0c;CI &#061;\u7f6e\u4fe1\u533a\u95f4\u3002<\/p>\n<\/p>\n<p class=\"img-center\"><img loading=\"lazy\" decoding=\"async\" alt=\"\u56fe\u7247\" class=\"rich_pages wxw-img\" height=\"1222\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/08\/20260803021703-6a6ffa1f36463.png\" width=\"1034\" \/><\/p>\n<p style=\"margin-left:0;margin-right:0\"><span style=\"color:#47c1a8\">\u529f\u80fd\u8fde\u901a\u6620\u5c04\u89e3\u6790\u6fc0\u9176\u6291\u5236\u5242\u673a\u5236\u76f8\u4f3c\u6027<\/span><\/p>\n<\/p>\n<p class=\"img-center\"><img loading=\"lazy\" decoding=\"async\" alt=\"\u56fe\u7247\" class=\"rich_pages wxw-img\" height=\"1350\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/08\/20260803021703-6a6ffa1fab00d.png\" width=\"882\" \/><\/p>\n<p style=\"margin-left:0;margin-right:0\">\u56fe3\u00a0\u00a0\u836f\u7269\u4e92\u4f5c\u7f51\u7edc\u4e0e\u5171\u6709\u901a\u8def\u5bcc\u96c6\u5206\u6790<\/p>\n<p style=\"margin-left:0;margin-right:0\">(a) 26\u79cd\u6fc0\u9176\u6291\u5236\u5242\u65e0\u5411\u529f\u80fd\u5173\u8054\u7f51\u7edc&#xff1b;\u8282\u70b9\u4e3a\u836f\u7269&#xff0c;\u8fde\u7ebf\u4ee3\u8868\u6821\u6b63P&lt;0.05\u663e\u8457\u5173\u8054&#xff1b;\u8fde\u7ebf\u989c\u8272 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style=\"margin-left:0;margin-right:0\">\u601d\u7ef4\u5bfc\u56fe<\/p>\n<p style=\"margin-left:0;margin-right:0\">\u6570\u636e\u5e93\u6570\u636e\u6e90\u603b\u89c8<\/p>\n<\/p>\n<p class=\"img-center\"><img loading=\"lazy\" decoding=\"async\" alt=\"\u56fe\u7247\" class=\"rich_pages wxw-img\" height=\"182\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/08\/20260803021704-6a6ffa208637c.png\" width=\"1080\" \/><\/p>\n<p style=\"margin-left:0;margin-right:0\">2\u6837\u672c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316&#xff08;MR&#xff09;\u56e0\u679c\u63a8\u65ad\u6a21\u5757<\/p>\n<\/p>\n<p class=\"img-center\"><img loading=\"lazy\" decoding=\"async\" alt=\"\u56fe\u7247\" class=\"rich_pages wxw-img\" height=\"171\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/08\/20260803021704-6a6ffa20a4592.png\" width=\"1080\" \/><\/p>\n<p style=\"margin-left:0;margin-right:0\">5\u4e2a\u5fc3\u808c\u57fa\u56e0\u529f\u80fd\u6a21\u5757<\/p>\n<\/p>\n<p class=\"img-center\"><img 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