{"id":89430,"date":"2026-08-03T00:56:32","date_gmt":"2026-08-02T16:56:32","guid":{"rendered":"https:\/\/www.wsisp.com\/helps\/89430.html"},"modified":"2026-08-03T00:56:32","modified_gmt":"2026-08-02T16:56:32","slug":"%e4%bf%9d%e5%a7%86%e7%ba%a7%e9%81%bf%e5%9d%91%e6%8c%87%e5%8d%97%ef%bc%9a%e6%89%8b%e6%8a%8a%e6%89%8b%e6%95%99%e4%bd%a0%e6%90%ad%e5%bb%ba%e6%9c%ac%e5%9c%b0ucsc%e5%9f%ba%e5%9b%a0%e7%bb%84%e6%b5%8f","status":"publish","type":"post","link":"https:\/\/www.wsisp.com\/helps\/89430.html","title":{"rendered":"\u4fdd\u59c6\u7ea7\u907f\u5751\u6307\u5357\uff1a\u624b\u628a\u624b\u6559\u4f60\u642d\u5efa\u672c\u5730UCSC\u57fa\u56e0\u7ec4\u6d4f\u89c8\u5668\u6570\u636e\u670d\u52a1\u5668\uff08\u542bbedGraphToBigWig\u5de5\u5177\u914d\u7f6e\uff09"},"content":{"rendered":"<h2>\u57fa\u56e0\u7ec4\u6570\u636e\u672c\u5730\u5316\u90e8\u7f72\u5b9e\u6218\uff1a\u4ece\u96f6\u6784\u5efa\u4f01\u4e1a\u7ea7UCSC\u6d4f\u89c8\u5668\u670d\u52a1\u73af\u5883<\/h2>\n<p>\u5728\u751f\u7269\u4fe1\u606f\u5b66\u7814\u7a76\u548c\u9ad8\u901a\u91cf\u6d4b\u5e8f\u5206\u6790\u4e2d\uff0c\u53ef\u89c6\u5316\u5de5\u5177\u7684\u91cd\u8981\u6027\u4e0d\u8a00\u800c\u55bb\u3002\u5bf9\u4e8e\u5904\u7406\u654f\u611f\u57fa\u56e0\u7ec4\u6570\u636e\u7684\u7814\u7a76\u673a\u6784\u6216\u4f01\u4e1a\u800c\u8a00\uff0c\u5c06\u539f\u59cb\u6d4b\u5e8f\u6570\u636e\u6216\u5206\u6790\u7ed3\u679c\u4e0a\u4f20\u81f3\u516c\u5171\u670d\u52a1\u5668\u5b58\u5728\u660e\u663e\u7684\u9690\u79c1\u4e0e\u5408\u89c4\u98ce\u9669\u3002\u8fd9\u6b63\u662f\u4e3a\u4ec0\u4e48\u8d8a\u6765\u8d8a\u591a\u7684\u56e2\u961f\u5f00\u59cb\u5bfb\u6c42\u672c\u5730\u5316\u90e8\u7f72\u89e3\u51b3\u65b9\u6848\u2014\u2014\u901a\u8fc7\u5728\u5185\u7f51\u642d\u5efa\u5b8c\u6574\u7684\u57fa\u56e0\u7ec4\u6d4f\u89c8\u5668\u670d\u52a1\u73af\u5883\uff0c\u65e2\u80fd\u4eab\u53d7\u4e13\u4e1a\u53ef\u89c6\u5316\u5de5\u5177\u7684\u5f3a\u5927\u529f\u80fd\uff0c\u53c8\u80fd\u786e\u4fdd\u6838\u5fc3\u6570\u636e\u4e0d\u51fa\u672c\u5730\u670d\u52a1\u5668\u3002<\/p>\n<p>\u672c\u6587\u5c06\u805a\u7126UCSC\u57fa\u56e0\u7ec4\u6d4f\u89c8\u5668\u7684\u672c\u5730\u5316\u90e8\u7f72\u5168\u6d41\u7a0b\uff0c\u7279\u522b\u9488\u5bf9bedGraph\u5230bigWig\u683c\u5f0f\u8f6c\u6362\u8fd9\u4e00\u5e38\u89c1\u9700\u6c42\u573a\u666f\uff0c\u63d0\u4f9b\u4ece\u5de5\u5177\u914d\u7f6e\u5230\u670d\u52a1\u53d1\u5e03\u7684\u5b8c\u6574\u6280\u672f\u65b9\u6848\u3002\u4e0d\u540c\u4e8e\u7b80\u5355\u7684\u8f6f\u4ef6\u5b89\u88c5\u6559\u7a0b\uff0c\u6211\u4eec\u4f1a\u6df1\u5165\u63a2\u8ba8\u5b9e\u9645\u90e8\u7f72\u8fc7\u7a0b\u4e2d\u53ef\u80fd\u9047\u5230\u7684\u5404\u7c7b\\&#8221;\u5751\u70b9\\&#8221;\uff0c\u5305\u62ec\u6743\u9650\u914d\u7f6e\u9677\u9631\u3001\u6587\u4ef6\u8def\u5f84\u5e38\u89c1\u9519\u8bef\u3001\u670d\u52a1\u517c\u5bb9\u6027\u95ee\u9898\u7b49\uff0c\u5e2e\u52a9IT\u8fd0\u7ef4\u4eba\u5458\u548c\u751f\u7269\u4fe1\u606f\u5b66\u7814\u7a76\u8005\u907f\u5f00\u90a3\u4e9b\u8017\u8d39\u6570\u5c0f\u65f6\u751a\u81f3\u6570\u5929\u7684\u5178\u578b\u90e8\u7f72\u969c\u788d\u3002<\/p>\n<h3>1. \u57fa\u7840\u73af\u5883\u51c6\u5907\u4e0e\u5de5\u5177\u94fe\u914d\u7f6e<\/h3>\n<h4>1.1 \u670d\u52a1\u5668\u7cfb\u7edf\u8981\u6c42\u4e0e\u4f9d\u8d56\u68c0\u67e5<\/h4>\n<p>UCSC\u57fa\u56e0\u7ec4\u6d4f\u89c8\u5668\u5de5\u5177\u94fe\u4e3b\u8981\u9488\u5bf9Linux\u73af\u5883\u5f00\u53d1\uff0c\u63a8\u8350\u4f7f\u7528CentOS 7+\u6216Ubuntu 18.04 LTS\u53ca\u4ee5\u4e0a\u7248\u672c\u3002\u90e8\u7f72\u524d\u9700\u786e\u8ba4\u7cfb\u7edf\u5df2\u5b89\u88c5\u4ee5\u4e0b\u57fa\u7840\u4f9d\u8d56\uff1a<\/p>\n<p># \u68c0\u67e5gcc\u548cmake\u662f\u5426\u5b89\u88c5<br \/>\ngcc &#8211;version<br \/>\nmake &#8211;version<\/p>\n<p># \u68c0\u67e5\u57fa\u7840\u5f00\u53d1\u5e93<br \/>\nldconfig -p | grep libssl<br \/>\nldconfig -p | grep zlib<\/p>\n<p>\u82e5\u7f3a\u5c11\u5fc5\u8981\u7ec4\u4ef6\uff0c\u53ef\u901a\u8fc7\u4ee5\u4e0b\u547d\u4ee4\u5b89\u88c5\uff08\u4ee5Ubuntu\u4e3a\u4f8b\uff09\uff1a<\/p>\n<p>sudo apt-get update<br \/>\nsudo apt-get install -y build-essential zlib1g-dev libssl-dev libcurl4-openssl-dev<\/p>\n<p>\u6ce8\u610f\uff1a\u90e8\u5206\u5de5\u5177\u5bf9GLIBC\u7248\u672c\u6709\u7279\u5b9a\u8981\u6c42\uff0c\u5728\u8f83\u8001\u7cfb\u7edf\u4e0a\u53ef\u80fd\u9700\u624b\u52a8\u5347\u7ea7\u57fa\u7840\u5e93\uff0c\u5efa\u8bae\u4f18\u5148\u4f7f\u7528\u8f83\u65b0\u7684Linux\u53d1\u884c\u7248\u3002<\/p>\n<h4>1.2 UCSC\u5de5\u5177\u96c6\u4e0b\u8f7d\u4e0e\u7f16\u8bd1<\/h4>\n<p>UCSC\u63d0\u4f9b\u7684\u57fa\u56e0\u7ec4\u6570\u636e\u5904\u7406\u5de5\u5177\u5e76\u672a\u6253\u5305\u4e3a\u73b0\u6210\u7684\u4e8c\u8fdb\u5236\u6587\u4ef6\uff0c\u9700\u8981\u4ece\u6e90\u7801\u7f16\u8bd1\u3002\u4ee5\u4e0b\u662f\u83b7\u53d6\u548c\u7f16\u8bd1\u5173\u952e\u5de5\u5177\u7684\u6807\u51c6\u5316\u6d41\u7a0b\uff1a<\/p>\n<p># \u521b\u5efa\u4e13\u7528\u5de5\u4f5c\u76ee\u5f55<br \/>\nmkdir -p \/opt\/ucsc_tools<br \/>\ncd \/opt\/ucsc_tools<\/p>\n<p># \u4e0b\u8f7d\u5de5\u5177\u6e90\u7801\u5305<br \/>\nwget http:\/\/hgdownload.soe.ucsc.edu\/admin\/exe\/linux.x86_64\/bedGraphToBigWig<br \/>\nwget http:\/\/hgdownload.soe.ucsc.edu\/admin\/exe\/linux.x86_64\/fetchChromSizes<br \/>\nchmod +x bedGraphToBigWig fetchChromSizes<\/p>\n<p>\u9a8c\u8bc1\u5de5\u5177\u662f\u5426\u53ef\u7528\uff1a&lt;\/<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u57fa\u56e0\u7ec4\u6570\u636e\u672c\u5730\u5316\u90e8\u7f72\u5b9e\u6218\uff1a\u4ece\u96f6\u6784\u5efa\u4f01\u4e1a\u7ea7UCSC\u6d4f\u89c8\u5668\u670d\u52a1\u73af\u5883<br \/>\n\u5728\u751f\u7269\u4fe1\u606f\u5b66\u7814\u7a76\u548c\u9ad8\u901a\u91cf\u6d4b\u5e8f\u5206\u6790\u4e2d\uff0c\u53ef\u89c6\u5316\u5de5\u5177\u7684\u91cd\u8981\u6027\u4e0d\u8a00\u800c\u55bb\u3002\u5bf9\u4e8e\u5904\u7406\u654f\u611f\u57fa\u56e0\u7ec4\u6570\u636e\u7684\u7814\u7a76\u673a\u6784\u6216\u4f01\u4e1a\u800c\u8a00\uff0c\u5c06\u539f\u59cb\u6d4b\u5e8f\u6570\u636e\u6216\u5206\u6790\u7ed3\u679c\u4e0a\u4f20\u81f3\u516c\u5171\u670d\u52a1\u5668\u5b58\u5728\u660e\u663e\u7684\u9690\u79c1\u4e0e\u5408\u89c4\u98ce\u9669\u3002\u8fd9\u6b63\u662f\u4e3a\u4ec0\u4e48\u8d8a\u6765\u8d8a\u591a\u7684\u56e2\u961f\u5f00\u59cb\u5bfb\u6c42\u672c\u5730\u5316\u90e8\u7f72\u89e3\u51b3\u65b9\u6848\u2014\u2014\u901a\u8fc7\u5728\u5185\u7f51\u642d\u5efa\u5b8c\u6574\u7684\u57fa\u56e0\u7ec4\u6d4f\u89c8\u5668\u670d\u52a1\u73af\u5883\uff0c\u65e2\u80fd\u4eab\u53d7\u4e13\u4e1a\u53ef\u89c6\u5316\u5de5\u5177\u7684\u5f3a\u5927\u529f\u80fd\uff0c\u53c8\u80fd\u786e\u4fdd\u6838\u5fc3\u6570\u636e\u4e0d\u51fa\u672c\u5730\u670d\u52a1\u5668\u3002<br \/>\n\u672c\u6587\u5c06\u805a\u7126UCSC\u57fa\u56e0\u7ec4\u6d4f\u89c8\u5668\u7684\u672c\u5730\u5316\u90e8\u7f72\u5168\u6d41\u7a0b\uff0c\u7279\u522b\u9488\u5bf9bedGrap<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[10146,10145,9143,2019],"topic":[],"class_list":["post-89430","post","type-post","status-publish","format-standard","hentry","category-server","tag-bedgraphtobigwig","tag-ucsc","tag-9143","tag-2019"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u4fdd\u59c6\u7ea7\u907f\u5751\u6307\u5357\uff1a\u624b\u628a\u624b\u6559\u4f60\u642d\u5efa\u672c\u5730UCSC\u57fa\u56e0\u7ec4\u6d4f\u89c8\u5668\u6570\u636e\u670d\u52a1\u5668\uff08\u542bbedGraphToBigWig\u5de5\u5177\u914d\u7f6e\uff09 - \u7f51\u7855\u4e92\u8054\u5e2e\u52a9\u4e2d\u5fc3<\/title>\n<meta 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