{"id":122301,"date":"2026-11-04T16:53:33","date_gmt":"2026-11-04T08:53:33","guid":{"rendered":"https:\/\/www.wsisp.com\/helps\/122301.html"},"modified":"2026-11-04T16:53:33","modified_gmt":"2026-11-04T08:53:33","slug":"%e4%bb%a3%e8%b0%a2-%e7%96%be%e7%97%85-%e9%81%97%e4%bc%a0%ef%bc%9a16%e9%a1%b9%e7%a0%94%e7%a9%b6%e3%80%812663%e6%9d%a1%e6%b5%8b%e9%87%8f","status":"publish","type":"post","link":"https:\/\/www.wsisp.com\/helps\/122301.html","title":{"rendered":"\u4ee3\u8c22\u2011\u75be\u75c5\u2011\u9057\u4f20\uff1a16\u9879\u7814\u7a76\u30012,663\u6761\u6d4b\u91cf"},"content":{"rendered":"

\u6458\u8981<\/h4>\n

\u4eba\u7fa4\u89c4\u6a21\u4ee3\u8c22\u7ec4\u5b66\u7814\u7a76\u5df2\u7ecf\u5efa\u7acb\u4ee3\u8c22\u68c0\u6d4b\u6307\u6807\u4e0e\u75be\u75c5\u3001\u6570\u91cf\u6027\u72b6\u4ee5\u53ca\u9057\u4f20\u53d8\u5f02\u4e4b\u95f4\u7684\u5173\u8054，\u4f46\u7814\u7a76\u7ed3\u679c\u5206\u6563\u5728\u4e0d\u540c\u68c0\u6d4b\u5e73\u53f0\u3001\u8868\u578b\u5b9a\u4e49\u4e0e\u5206\u6790\u683c\u5f0f\u4e2d\u3002MetabDB\u6574\u540816\u9879\u516c\u5f00\u7814\u7a76\u6570\u636e，\u8986\u76d6\u6838\u78c1\u5171\u632f\u3001\u8d28\u8c31\u3001\u8102\u8d28\u7ec4\u5b66\u6280\u672f\u3002\u5f53\u524d\u7248\u672c\u5305\u542b2,663\u9879\u4ee3\u8c22\u68c0\u6d4b\u6307\u6807\u30013,524\u79cd\u75be\u75c5\u4e0e\u4e34\u5e8a\u7ed3\u5c40\u30013,382\u9879\u5176\u4ed6\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u6027\u72b6，\u4ee5\u53ca2,025\u4e2a\u5206\u5b50\u6570\u91cf\u6027\u72b6\u4f4d\u70b9（QTL）\u9776\u70b9\u3002MetabDB\u901a\u8fc7\u53d8\u5f02\u2011QTL\u5173\u8054\u3001\u7cbe\u7ec6\u5b9a\u4f4d\u3001\u7a00\u6709\u53d8\u5f02\/\u8d1f\u8377\u5206\u6790\u3001\u5171\u5b9a\u4f4d\u3001\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u4ee5\u53ca\u4eba\u7fa4\u5173\u8054\u5206\u6790，\u5c06\u57fa\u56e0\u7ec4\u53d8\u5f02\u3001\u57fa\u56e0\u3001\u86cb\u767d\u3001\u4ee3\u8c22\u68c0\u6d4b\u6307\u6807\u3001\u75be\u75c5\/\u6027\u72b6\u5173\u8054\u8d77\u6765\u3002\u4ee3\u8c22\u68c0\u6d4b\u6307\u6807\u4fdd\u7559\u539f\u59cb\u6587\u732e\u62a5\u9053\u5f62\u5f0f，\u5305\u542b\u5316\u5408\u7269\u3001\u8102\u8d28\u5206\u5b50\u3001\u8102\u86cb\u767d\u6307\u6807\u3001\u6bd4\u503c\u3001\u767e\u5206\u6bd4\u4ee5\u53ca\u884d\u751f\u6027\u72b6\u3002\u9488\u5bf9\u540c\u4e00\u4ee3\u8c22\u6307\u6807，\u53ef\u540c\u65f6\u67e5\u770b\u57fa\u56e0\u3001\u86cb\u767d\u5c42\u9762\u8bc1\u636e\u3001\u57fa\u56e0\u7ec4\u4fe1\u53f7\u4ee5\u53ca\u5bf9\u5e94\u7684\u75be\u75c5\u6216\u6027\u72b6\u8bc1\u636e\u3002\u6570\u636e\u5e93\u5b8c\u6574\u4fdd\u7559\u6765\u6e90\u4fe1\u606f\u4e0e\u5206\u6790\u7ec6\u8282，\u5305\u62ec\u539f\u59cb\u7814\u7a76\u3001\u53d8\u91cf\/\u8868\u578b\u5b9a\u4e49\u3001\u68c0\u6d4b\u6280\u672f\u3001\u5355\u4f4d\u3001\u66b4\u9732\u5c3a\u5ea6\u3001\u5206\u6790\u6a21\u578b\u4ee5\u53ca\u7edf\u8ba1\u7ed3\u679c\u3002\u7528\u6237\u53ef\u901a\u8fc7\u68c0\u7d22\u3001\u6d4f\u89c8\u3001\u5171\u5b9a\u4f4d\u9875\u9762，\u7ed3\u5408\u57fa\u56e0\u8bc1\u636e\u5e7f\u5ea6\u5206\u6790\u3001\u75be\u75c5\u5173\u8054\u8c31\u8bbf\u95ee\u5168\u90e8\u8bb0\u5f55\u3002MetabDB\u514d\u8d39\u5f00\u653e\u8bbf\u95ee：<\/p>\n

http:\/\/www.mulinlab.org\/metabdb\/<\/p>\n

ddhuang@tmu.edu.cn<\/p>\n

#\u4ee3\u8c22\u68c0\u6d4b\u6307\u6807\u00a0#\u4ee3\u8c22\u7ec4\u5b66\u00a0#\u6570\u91cf\u6027\u72b6\u4f4d\u70b9\u00a0#\u5171\u5b9a\u4f4d\u00a0#\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u00a0#\u7a00\u6709\u53d8\u5f02\u5206\u6790\u00a0#\u75be\u75c5\u2011\u4ee3\u8c22\u5173\u8054\u00a0#MetabDB\u00a0<\/p>\n<\/p>\n

\"\u56fe\u7247\"<\/p>\n

\u5f15\u8a00<\/h4>\n<\/p>\n

\"\u56fe\u7247\"<\/p>\n

\u56fe1\u00a0\u00a0MetabDB\u6570\u636e\u5e93\u6574\u4f53\u6846\u67b6<\/p>\n

MetabDB\u7684\u6570\u636e\u6765\u6e90\u3001\u5b9e\u4f53\u5173\u7cfb\u4e0e\u529f\u80fd\u6846\u67b6\u3002\u6570\u636e\u5e93\u6574\u5408\u6765\u81ea\u6838\u78c1\u5171\u632f\u3001\u8d28\u8c31\u3001\u8102\u8d28\u7ec4\u5b66\u5e73\u53f0\u7684\u4eba\u7fa4\u4ee3\u8c22\u7ec4\u6570\u636e，\u6536\u5f55\u53d8\u5f02\u3001\u57fa\u56e0\u3001\u86cb\u767d\u3001\u4ee3\u8c22\u68c0\u6d4b\u6307\u6807\u3001\u75be\u75c5\/\u6027\u72b65\u5927\u6838\u5fc3\u5b9e\u4f53\u3002\u4f9d\u6258\u53d8\u5f02\u2011QTL\u5173\u8054\u3001\u7cbe\u7ec6\u5b9a\u4f4d\u3001\u7a00\u6709\u53d8\u5f02\u8d1f\u8377\u5206\u6790\u3001\u5171\u5b9a\u4f4d\u3001\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u3001\u4eba\u7fa4\u8868\u578b\u5173\u8054\u591a\u79cd\u8bc1\u636e，\u642d\u5efa\u5b9e\u4f53\u95f4\u7684\u5173\u8054\u94fe\u8def\u3002\u5e73\u53f0\u63d0\u4f9b\u68c0\u7d22\u3001\u6d4f\u89c8\u3001\u5171\u5b9a\u4f4d\u53ef\u89c6\u5316\u3001\u8bc1\u636e\u6c47\u603b\u3001\u6848\u4f8b\u89e3\u6790\u529f\u80fd，\u5168\u90e8\u6570\u636e\u652f\u6301\u7f51\u9875\u6d4f\u89c8\u4e0e\u6279\u91cf\u4e0b\u8f7d\u3002<\/p>\n

\u7ed3\u679c<\/h4>\n

\u6570\u636e\u5e93\u5b9e\u4f53\u4e0e\u6570\u636e\u8986\u76d6<\/p>\n<\/p>\n

\"\u56fe\u7247\"<\/p>\n

\u56fe2\u00a0\u00a0MetabDB\u4e2d\u4ee3\u8c22\u6307\u6807\u3001\u8868\u578b\u53ca\u5404\u7c7b\u8bc1\u636e\u7684\u8986\u76d6\u60c5\u51b5<\/p>\n

(A) 2,663\u9879\u4ee3\u8c22\u68c0\u6d4b\u6307\u6807\u6309\u7167\u6d4b\u91cf\u5f62\u5f0f\u3001\u68c0\u6d4b\u5e73\u53f0\u7684\u5206\u5e03；<\/p>\n

(B) 3,524\u79cd\u75be\u75c5\u4e0e\u4e34\u5e8a\u7ed3\u5c40\u6309\u7167\u4e34\u5e8a\u7cfb\u7edf\u5206\u7c7b\u5206\u5e03；<\/p>\n

(C) 3,382\u9879\u5176\u4ed6GWAS\u6027\u72b6\u6309\u7167\u6027\u72b6\u7c7b\u578b\u5206\u5e03；<\/p>\n

(D) \u53d1\u75c5\u3001\u60a3\u75c5\u3001\u6b7b\u4ea1\u5173\u8054\u7684\u539f\u59cb\u8bb0\u5f55\u6570\u91cf；<\/p>\n

(E) \u5171\u5b9a\u4f4d\u3001\u5b5f\u5fb7\u5c14\u968f\u673a\u5316MR\u652f\u6301\u7684\u4e0d\u540c\u5b9e\u4f53\u914d\u5bf9\u6570\u91cf\u3002<\/p>\n

\u8de8\u5b9e\u4f53\u68c0\u7d22\u4e0e\u6574\u5408\u8bc1\u636e\u9875\u9762<\/p>\n<\/p>\n

\"\u56fe\u7247\"<\/p>\n

\u56fe3\u00a0\u00a0\u8461\u8404\u7cd6\u7684\u6574\u5408\u8bc1\u636e\u89c6\u56fe<\/p>\n

(A) \u4e0e\u8461\u8404\u7cd6\u5173\u8054\u7684\u5168\u57fa\u56e0\u7ec4\u9057\u4f20\u4e0e\u5206\u5b50\u8bc1\u636e\u3002\u53d8\u5f02\u5c42\u9762\u8bc1\u636e\u6cbfGRCh38\u57fa\u56e0\u7ec4\u5750\u6807\u5c55\u793a，\u540c\u65f6\u5bf9\u9f50\u57fa\u56e0\u3001\u86cb\u767d\u8bc1\u636e；\u53f3\u4fa7\u8868\u683c\u5217\u51fa\u90e8\u5206\u75be\u75c5\u76f8\u5173\u5171\u5b9a\u4f4d\u4e0eMR\u8bc1\u636e\u3002<\/p>\n

(B) \u9009\u5b9a\u75be\u75c5\/\u6027\u72b6\u7684\u4e34\u5e8a\u5173\u8054\u6c47\u603b，\u5305\u542bHR\u98ce\u9669\u6bd4\u3001OR\u6bd4\u503c\u6bd4\u3001RR\u98ce\u9669\u6bd4\u3001P\u503c\u3001\u6821\u6b63 P\u503c\u3001\u6821\u6b63\u65b9\u6cd5\u3002\u4e0b\u65b9\u8868\u683c\u5c55\u793a\u8461\u8404\u7cd6\u20112\u578b\u7cd6\u5c3f\u75c5\u5173\u7cfb\u5bf9\u5e94\u7684\u539f\u59cb\u6765\u6e90\u8bb0\u5f55，\u5305\u542b\u961f\u5217\u3001\u7ed3\u5c40\u4e0e\u5206\u6790\u6a21\u578b\u3001\u6548\u5e94\u503c\u4e0e\u7f6e\u4fe1\u533a\u95f4\u3001\u6d4b\u91cf\u5c3a\u5ea6\u3001\u7edf\u8ba1\u663e\u8457\u6027\u3001\u6837\u672c\u91cf\u3002\u539f\u59cb\u8bb0\u5f55\u5206\u5f00\u5c55\u793a，\u4e0d\u505a\u5408\u5e76\u6c47\u603b\u3002<\/p>\n

\u6848\u4f8b\u7814\u7a76<\/p>\n<\/p>\n

\"\u56fe\u7247\"<\/p>\n

\u56fe4\u00a0\u00a0MetabDB\u4e2dGlycA\u20112\u578b\u7cd6\u5c3f\u75c5\u7684\u8bc1\u636e<\/p>\n

(A) GlycA\u7684\u75be\u75c5\u8bc1\u636e，\u5305\u542b\u6c47\u603b\u7edf\u8ba1\u3001\u76f4\u63a5\u5173\u8054\u7ed3\u679c\u3001\u75be\u75c5\u76f8\u5173\u5171\u5b9a\u4f4d\u4e0eMR\u8bc1\u636e；\u9ad8\u4eae\u6807\u6ce82\u578b\u7cd6\u5c3f\u75c5\u3002<\/p>\n

(B) \u4e0eGlycA\u5173\u8054\u7684\u90e8\u5206\u57fa\u56e0\u3001\u86cb\u767d\u8bc1\u636e，\u5305\u542b\u57fa\u56e0\u529f\u80fd\u3001\u7a00\u6709\u53d8\u5f02\/\u8d1f\u8377\u8bc1\u636e\u3001\u57fa\u56e0\u5171\u5b9a\u4f4d\u6700\u5927PP.H4\u3001\u86cb\u767d\u5171\u5b9a\u4f4d\u8bc1\u636e\u3001\u6765\u6e90\u7814\u7a76\u6570\u91cf\u3002<\/p>\n<\/p>\n

\"\u56fe\u7247\"<\/p>\n

\u56fe5\u00a0\u00a0MetabDB\u4e2d\u808c\u9150\u4e0e\u6162\u6027\u80be\u75c5\u7684\u8bc1\u636e<\/p>\n

(A) \u4e0d\u540c\u75be\u75c5\u7cfb\u7edf\u4e0b\u808c\u9150\u7684\u53d1\u75c5\u7ed3\u5c40Cox\u98ce\u9669\u6bd4；\u9ad8\u4eae\u6162\u6027\u80be\u75c5，\u53f3\u4fa7\u5c55\u793a\u539f\u59cb\u7814\u7a76\u3001\u7ed3\u5c40\u3001\u6548\u5e94\u4f30\u8ba1\u3001\u66b4\u9732\u5c3a\u5ea6\u3001\u663e\u8457\u6027\u4fe1\u606f\u3002<\/p>\n

(B) \u90e8\u5206\u808c\u9150\u5173\u8054\u57fa\u56e0，\u5305\u542b\u57fa\u56e0\u529f\u80fd\u3001\u7a00\u6709\u53d8\u5f02\/\u8d1f\u8377\u8bc1\u636e\u3001\u57fa\u56e0\u5171\u5b9a\u4f4d\u6700\u5927PP.H4\u3001\u86cb\u767d\u5171\u5b9a\u4f4d\u8bc1\u636e\u3001\u7814\u7a76\u8ba1\u6570\u3002<\/p>\n

(C) \u808c\u9150\u2011\u6162\u6027\u80be\u75c5\u5173\u7cfb\u7684\u539f\u59cbMR\u7ed3\u679c，\u5305\u542b\u5206\u6790\u65b9\u5411\u3001\u65b9\u6cd5\u3001\u5de5\u5177\u53d8\u91cf\u6570\u91cf\u3001\u6548\u5e94\u503c\u3001\u7f6e\u4fe1\u533a\u95f4\u3001P\u503c\u3001\u6821\u6b63P\u503c\u3002<\/p>\n

\u8be6\u7ec6\u603b\u7ed3<\/h4>\n<\/p>\n

\"\u56fe\u7247\"<\/p>\n

\u601d\u7ef4\u5bfc\u56fe<\/p>\n

\u7814\u7a76\u80cc\u666f<\/p>\n<\/p>\n

\"\u56fe\u7247\"<\/p>\n

MetabDB \u4e94\u5927\u6838\u5fc3\u5b9e\u4f53（E1\u2011E5）<\/p>\n<\/p>\n

\"\u56fe\u7247\"<\/p>\n

\u5b9e\u4f53\u4e4b\u95f4\u8bc1\u636e\u5173\u8054\u5927\u7c7b<\/p>\n<\/p>\n

\"\u56fe\u7247\"<\/p>\n

\u5173\u952e\u8bc1\u636e\u89c4\u6a21<\/p>\n<\/p>\n

\"\u56fe\u7247\"<\/p>\n

\u6570\u636e\u5e93\u7f51\u9875\u6838\u5fc3\u529f\u80fd<\/p>\n<\/p>\n

\"\u56fe\u7247\"<\/p>\n

MetabDB\u4e0e\u540c\u7c7b\u8d44\u6e90\u6a2a\u5411\u5bf9\u6bd4<\/p>\n<\/p>\n

\"\u56fe\u7247\"<\/p>\n

\u53c2\u8003<\/h5>\n

Nucleic Acids Res. 2026 Oct 31:gkag1086. doi: 10.1093\/nar\/gkag1086.\u00a0<\/p>\n

MetabDB: an integrated resource for human metabolic measures, disease associations, and genetic evidence<\/p>\n<\/p>\n

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