{"id":121946,"date":"2026-11-04T01:57:29","date_gmt":"2026-11-03T17:57:29","guid":{"rendered":"https:\/\/www.wsisp.com\/helps\/121946.html"},"modified":"2026-11-04T01:57:29","modified_gmt":"2026-11-03T17:57:29","slug":"brief-bioinform-%e6%8a%93%e4%bd%8f%e8%bf%99%e4%b8%aa%e8%a1%b0%e8%80%81%e7%83%ad%e7%82%b9%ef%bc%8110753%e4%bb%bd%e8%a1%80%e6%b6%b2%e8%bd%ac%e5%bd%95%e7%bb%84%ef%bc%9abap%e7%94%a8%e5%81%a5%e5%ba%b7","status":"publish","type":"post","link":"https:\/\/www.wsisp.com\/helps\/121946.html","title":{"rendered":"Brief. Bioinform. | \u6293\u4f4f\u8fd9\u4e2a\u8870\u8001\u70ed\u70b9\uff0110753\u4efd\u8840\u6db2\u8f6c\u5f55\u7ec4\uff1aBAP\u7528\u5065\u5eb7\u8870\u8001\u53c2\u7167\uff0c\u8861\u91cf\u75be\u75c5\u5206\u5b50\u6270\u52a8"},"content":{"rendered":"<p>\u6a21\u578b\u9884\u6d4b\u7684\u5e74\u9f84&#xff0c;\u6bd4\u5b9e\u9645\u5e74\u9f84\u9ad8\u51fa9.34\u5c81\u3002<\/p>\n<p>\u8fd9\u4e2a\u6570\u5b57\u770b\u8d77\u6765\u5f88\u76f4\u89c2&#xff0c;\u4f46\u5b83\u7a76\u7adf\u6d4b\u91cf\u4e86\u4ec0\u4e48&#xff1f;<\/p>\n<p>\u662f\u4eba\u4f53\u6c38\u4e45\u201c\u8001\u4e869\u5c81\u201d&#xff0c;\u8fd8\u662f\u611f\u67d3\u540e\u7684\u708e\u75c7\u3001\u514d\u75ab\u7ec6\u80de\u7ec4\u6210\u548c\u5e94\u6fc0\u53cd\u5e94&#xff0c;\u8ba9\u8840\u6db2\u8f6c\u5f55\u7ec4\u6682\u65f6\u504f\u79bb\u4e86\u5065\u5eb7\u72b6\u6001&#xff1f;<\/p>\n<p>2026\u5e7410\u670830\u65e5\u53d1\u8868\u4e8e Briefings in Bioinformatics \u7684\u4e00\u9879\u7814\u7a76&#xff0c;\u5c06\u8fd9\u4e2a\u95ee\u9898\u653e\u8fdb\u4e86\u4e00\u4e2a\u516c\u5171\u6570\u636e\u6846\u67b6&#xff1a;\u6574\u5408 23\u4e2a\u961f\u5217\u300110,753\u4efd\u5168\u8840\u8f6c\u5f55\u7ec4\u8c31&#xff0c;\u5148\u7528\u5065\u5eb7\u6837\u672c\u5efa\u7acb\u5e74\u9f84\u53c2\u7167&#xff0c;\u518d\u89c2\u5bdf\u75be\u75c5\u6837\u672c\u504f\u79bb\u591a\u5c11&#xff0c;\u4ee5\u53ca\u504f\u79bb\u5bf9\u5e94\u54ea\u4e9b\u5206\u5b50\u53d8\u5316\u3002<\/p>\n<p>\u7814\u7a76\u63d0\u51fa\u7684\u6a21\u578b\u53eb BAP&#xff0c;blood aging predictor\u3002<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/11\/20261103175719-6aea207f4736a.png\" alt=\"\" \/><\/p>\n<p>\u8fd9\u7bc7\u6587\u7ae0\u503c\u5f97\u5173\u6ce8\u7684\u7814\u7a76\u601d\u8def\u662f&#xff1a;\u628a\u5065\u5eb7\u4eba\u7fa4\u4e2d\u7684\u8fde\u7eed\u53d8\u5316&#xff0c;\u4f5c\u4e3a\u8861\u91cf\u75be\u75c5\u6270\u52a8\u7684\u53c2\u7167\u3002 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\u6b63\u5f0f\u7814\u7a76\u8bba\u6587&#xff0c;2026\u5e7410\u670830\u65e5\u5728\u7ebf\u53d1\u8868\u3002<\/p>\n<h3>\u5148\u5efa\u7acb\u53c2\u7167&#xff0c;\u518d\u89e3\u91ca\u75be\u75c5<\/h3>\n<p>\u8bb8\u591a\u75be\u75c5\u8f6c\u5f55\u7ec4\u7814\u7a76&#xff0c;\u4ece\u201c\u60a3\u8005\u5bf9\u5065\u5eb7\u4eba\u201d\u7684\u5dee\u5f02\u5206\u6790\u5f00\u59cb\u3002<\/p>\n<p>\u4f5c\u8005\u589e\u52a0\u4e86\u4e00\u6761\u53c2\u7167\u8f74&#xff1a;\u5065\u5eb7\u4eba\u7fa4\u7684\u5e74\u9f84\u3002<\/p>\n<p>\u4ed6\u4eec\u5148\u6574\u54089\u4e2a\u8870\u8001\u76f8\u5173\u961f\u5217&#xff0c;\u51716,491\u4efd\u6837\u672c&#xff0c;\u5206\u6790\u8868\u8fbe\u968f\u5e74\u9f84\u53d8\u5316\u7684\u65b9\u5411&#xff1b;\u518d\u4e0eCOVID-19\u76f8\u5173\u8f6c\u5f55\u53d8\u5316\u6bd4\u8f83&#xff0c;\u68c0\u67e5\u4e24\u8005\u662f\u5426\u5b58\u5728\u5171\u540c\u90e8\u5206\u3002<\/p>\n<p>\u7ed3\u679c\u63d0\u793a&#xff0c;\u611f\u67d3\u4e0e\u5e74\u9f84\u589e\u957f\u90fd\u6d89\u53ca\u90e8\u5206\u514d\u75ab\u3001\u708e\u75c7\u53ca\u7ec6\u80de\u7a33\u6001\u76f8\u5173\u7a0b\u5e8f\u3002<\/p>\n<p>\u4f46\u76f8\u4f3c\u7a0b\u5ea6\u9700\u8981\u770b\u6548\u5e94\u5927\u5c0f&#xff1a;\u57fa\u56e0\u5c42\u9762\u7684\u6574\u4f53\u76f8\u5173\u7cfb\u6570\u4ec5\u4e3a0.117&#xff0c;\u867d\u7136\u7edf\u8ba1\u663e\u8457&#xff0c;\u76f8\u5173\u6027\u4ecd\u7136\u8f83\u5f31\u3002 \u90e8\u5206\u5171\u540c\u4e0b\u8c03\u901a\u8def\u7684\u76f8\u5173\u6027\u4e5f\u672a\u8fbe\u5230\u663e\u8457\u3002<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/11\/20261103175719-6aea207f65e14.png\" alt=\"\" \/><\/p>\n<p>\u539f\u6587\u56fe1&#xff5c;\u6bd4\u8f83\u5065\u5eb7\u5e74\u9f84\u76f8\u5173\u53d8\u5316\u4e0eCOVID-19\u76f8\u5173\u53d8\u5316&#xff0c;\u4e3a\u540e\u7eed\u5efa\u7acb\u5e74\u9f84\u53c2\u7167\u63d0\u4f9b\u4f9d\u636e\u3002<\/p>\n<p>\u56e0\u6b64&#xff0c;\u8fd9\u4e00\u6b65\u652f\u6301\u7684\u662f&#xff1a;\u4e24\u79cd\u72b6\u6001\u5b58\u5728\u90e8\u5206\u5171\u4eab\u7684\u8f6c\u5f55\u53d8\u5316&#xff0c;\u503c\u5f97\u8fdb\u4e00\u6b65\u91cf\u5316\u3002<\/p>\n<p>\u5b83\u5c1a\u4e0d\u8db3\u4ee5\u8bf4\u660e&#xff0c;\u611f\u67d3\u590d\u5236\u4e86\u5065\u5eb7\u8870\u8001\u7684\u5168\u90e8\u8fc7\u7a0b\u3002<\/p>\n<p>\u5bf9\u81ea\u5df1\u7684\u8bfe\u9898&#xff0c;\u8fd9\u4e2a\u8d77\u70b9\u53ef\u4ee5\u501f\u9274&#xff1a;\u5728\u8bad\u7ec3\u8bc4\u5206\u524d&#xff0c;\u5148\u8bf4\u660e\u4e3a\u4ec0\u4e48\u9009\u62e9\u8fd9\u6761\u53c2\u7167\u8f74&#xff0c;\u4ee5\u53ca\u5b83\u4e0e\u76ee\u6807\u75be\u75c5\u7a76\u7adf\u5171\u4eab\u54ea\u4e9b\u4fe1\u606f\u3002<\/p>\n<h3>BAP\u600e\u6837\u628a\u8868\u8fbe\u8c31\u6362\u7b97\u6210\u5e74\u9f84&#xff1f;<\/h3>\n<p>\u4f5c\u8005\u4ece\u8870\u8001\u961f\u5217\u4e2d\u6392\u9664\u6709\u660e\u786e\u75be\u75c5\u8bb0\u5f55\u7684\u6837\u672c&#xff0c;\u4fdd\u75595,808\u540d\u5065\u5eb7\u4e2a\u4f53\u7528\u4e8e\u6a21\u578b\u5f00\u53d1\u3002<\/p>\n<p>\u6700\u7ec8\u8f93\u5165\u5305\u62ec&#xff1a;<\/p>\n<table>\n<tr>\u7279\u5f81\u7c7b\u522b\u6570\u91cf<\/tr>\n<tbody>\n<tr>\n<td>\u5e74\u9f84\u76f8\u5173\u57fa\u56e0\u8868\u8fbe<\/td>\n<td align=\"right\">398<\/td>\n<\/tr>\n<tr>\n<td>\u4f30\u8ba1\u7684\u8840\u6db2\u7ec6\u80de\u7ec4\u6210<\/td>\n<td align=\"right\">11<\/td>\n<\/tr>\n<tr>\n<td>\u5e74\u9f84\u76f8\u5173\u901a\u8def\u8bc4\u5206<\/td>\n<td align=\"right\">12<\/td>\n<\/tr>\n<tr>\n<td>\u63a8\u65ad\u7684\u6027\u522b\u4fe1\u606f<\/td>\n<td align=\"right\">1<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u5408\u8ba1422\u9879\u3002<\/p>\n<p>\u7ec6\u80de\u7ec4\u6210\u3001\u901a\u8def\u53ca\u6027\u522b\u7279\u5f81\u4e5f\u6765\u81ea\u8f6c\u5f55\u7ec4\u4f30\u8ba1&#xff0c;\u5c5e\u4e8e\u540c\u4e00\u6570\u636e\u7684\u4e0d\u540c\u8868\u793a\u3002<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/11\/20261103175721-6aea2081a9225.png\" alt=\"\" \/><\/p>\n<p>\u539f\u6587\u56fe2&#xff5c;BAP\u7684\u7279\u5f81\u6784\u5efa\u3001\u6570\u636e\u5212\u5206&#xff0c;\u4ee5\u53ca\u5185\u90e8\u3001\u8c03\u53c2\u4e0e\u72ec\u7acb\u5916\u90e8\u6d4b\u8bd5\u8868\u73b0\u3002<\/p>\n<p>\u4f5c\u8005\u6bd4\u8f83\u591a\u79cd\u6a21\u578b&#xff0c;\u6700\u7ec8\u91c7\u7528\u5e26\u6709\u504f\u5dee\u7ea6\u675f\u4e0e\u5206\u5e03\u5bf9\u9f50\u7b56\u7565\u7684\u795e\u7ecf\u7f51\u7edc\u96c6\u6210\u3002<\/p>\n<p>\u4e0d\u8fc7&#xff0c;\u8bfb\u6a21\u578b\u8868\u73b0\u65f6&#xff0c;\u5e94\u8be5\u5148\u5206\u6e05\u6570\u636e\u627f\u62c5\u7684\u89d2\u8272&#xff1a;<\/p>\n<table>\n<tr>\u6570\u636e\u89d2\u8272\u5e73\u5747\u7edd\u5bf9\u8bef\u5dee\u89e3\u91ca\u65f6\u9700\u8981\u6ce8\u610f<\/tr>\n<tbody>\n<tr>\n<td>\u5185\u90e8\u6d4b\u8bd5<\/td>\n<td align=\"right\">3.47\u5e74<\/td>\n<td>\u7279\u5f81\u7b5b\u9009\u53d1\u751f\u5728\u5185\u90e8\u6570\u636e\u5212\u5206\u4e4b\u524d&#xff0c;\u8868\u73b0\u53ef\u80fd\u504f\u4e50\u89c2<\/td>\n<\/tr>\n<tr>\n<td>\u5916\u90e8\u8c03\u53c2<\/td>\n<td align=\"right\">3.49\u5e74<\/td>\n<td>\u53c2\u4e0e\u6a21\u578b\u4f18\u5316&#xff0c;\u4e0d\u80fd\u4f5c\u4e3a\u6700\u7ec8\u6cdb\u5316\u6210\u7ee9<\/td>\n<\/tr>\n<tr>\n<td>9\u4e2a\u72ec\u7acb\u5916\u90e8\u961f\u5217<\/td>\n<td align=\"right\">5.81\u5e74<\/td>\n<td>\u66f4\u6709\u52a9\u4e8e\u5224\u65ad\u8de8\u961f\u5217\u8868\u73b0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u8fd9\u4e9b\u8fb9\u754c&#xff0c;\u4f5c\u8005\u5728\u6b63\u6587\u4e2d\u4e5f\u8fdb\u884c\u4e86\u8bf4\u660e\u3002<\/p>\n<p>\u8fd9\u91cc\u6709\u4e24\u4e2a\u4e0d\u540c\u76ee\u6807&#xff1a;\u5728\u5065\u5eb7\u6837\u672c\u4e2d\u9884\u6d4b\u5e74\u9f84&#xff1b;\u5c06\u75be\u75c5\u6837\u672c\u6295\u5c04\u5230\u8fd9\u4e2a\u5e74\u9f84\u53c2\u7167\u3002<\/p>\n<p>\u5065\u5eb7\u5e74\u9f84\u9884\u6d4b\u8f83\u51c6\u786e&#xff0c;\u662f\u4f7f\u7528\u8fd9\u6761\u53c2\u7167\u7684\u57fa\u7840&#xff0c;\u5374\u4e0d\u80fd\u5355\u72ec\u8bc1\u660e\u75be\u75c5\u6837\u672c\u4e2d\u7684\u9884\u6d4b\u504f\u5dee\u5c31\u662f\u751f\u7269\u5b66\u8870\u8001\u3002<\/p>\n<h3>9.34\u5e74&#xff0c;\u5b9e\u9645\u662f\u600e\u6837\u7b97\u51fa\u6765\u7684&#xff1f;<\/h3>\n<p>BAP\u5e94\u7528\u5230COVID-19\u6837\u672c\u540e&#xff0c;\u9884\u6d4b\u5e74\u9f84\u6574\u4f53\u5411\u8f83\u9ad8\u65b9\u5411\u79fb\u52a8\u3002<\/p>\n<p>\u4f5c\u8005\u5148\u8ba1\u7b97\u201c\u9884\u6d4b\u5e74\u9f84\u51cf\u5b9e\u9645\u5e74\u9f84\u201d&#xff0c;\u518d\u7528\u6bcf\u4e2a\u961f\u5217\u4e2d\u5065\u5eb7\u5bf9\u7167\u7684\u5e73\u5747\u504f\u5dee\u4f5c\u57fa\u7ebf\u6821\u6b63&#xff0c;\u5f97\u5230\u75be\u75c5\u76f8\u5173\u7684 AgeAccel\u3002<\/p>\n<p>\u5728\u8fd9\u4e00\u5904\u7406\u6846\u67b6\u4e0b&#xff0c;COVID-19\u6837\u672c\u7684\u5e73\u5747AgeAccel\u4e3a9.34\u5e74\u3002<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/11\/20261103175723-6aea208350d55.png\" alt=\"\" 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decoding=\"async\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/11\/20261103175725-6aea208595ffc.png\" alt=\"\" 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decoding=\"async\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/11\/20261103175726-6aea20864290f.png\" alt=\"\" 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https:\/\/doi.org\/10.1093\/bib\/bbag605<\/p>\n<\/li>\n<li>\n<p>PubMed\u8bba\u6587\u8bb0\u5f55&#xff1a; https:\/\/pubmed.ncbi.nlm.nih.gov\/42960996\/<\/p>\n<\/li>\n<li>\n<p>PMC\u5f00\u653e\u5168\u6587\u53ca\u8865\u5145\u6750\u6599\u5165\u53e3&#xff1a; https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC13720740\/<\/p>\n<\/li>\n<li>\n<p>\u5206\u6790\u4ee3\u7801\u3001\u9884\u5904\u7406\u811a\u672c\u4e0e\u6a21\u578b\u8d44\u6e90&#xff1a; https:\/\/github.com\/YANGMTSYMQ\/BAP<\/p>\n<\/li>\n<li>\n<p>\u6a21\u578b\u5f00\u53d1\u6570\u636e\u793a\u4f8b&#xff0c;GSE203024&#xff1a; https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc&#061;GSE203024<\/p>\n<\/li>\n<li>\n<p>\u5916\u90e8\u8c03\u53c2\u961f\u5217&#xff0c;GSE177044&#xff1a; https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc&#061;GSE177044<\/p>\n<\/li>\n<li>\n<p>\u72ec\u7acb\u5916\u90e8\u6d4b\u8bd5\u961f\u5217\u4e4b\u4e00&#xff0c;GSE111368&#xff1a; https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc&#061;GSE111368<\/p>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u6a21\u578b\u9884\u6d4b\u7684\u5e74\u9f84&#xff0c;\u6bd4\u5b9e\u9645\u5e74\u9f84\u9ad8\u51fa9.34\u5c81\u3002<br \/>\n\u8fd9\u4e2a\u6570\u5b57\u770b\u8d77\u6765\u5f88\u76f4\u89c2&#xff0c;\u4f46\u5b83\u7a76\u7adf\u6d4b\u91cf\u4e86\u4ec0\u4e48&#xff1f;<br \/>\n\u662f\u4eba\u4f53\u6c38\u4e45\u201c\u8001\u4e869\u5c81\u201d&#xff0c;\u8fd8\u662f\u611f\u67d3\u540e\u7684\u708e\u75c7\u3001\u514d\u75ab\u7ec6\u80de\u7ec4\u6210\u548c\u5e94\u6fc0\u53cd\u5e94&#xff0c;\u8ba9\u8840\u6db2\u8f6c\u5f55\u7ec4\u6682\u65f6\u504f\u79bb\u4e86\u5065\u5eb7\u72b6\u6001&#xff1f;<br \/>\n2026\u5e7410\u670830\u65e5\u53d1\u8868\u4e8e Briefings in Bioinformatics \u7684\u4e00\u9879\u7814\u7a76&#xff0c;\u5c06\u8fd9\u4e2a\u95ee\u9898\u653e\u8fdb\u4e86\u4e00\u4e2a\u516c\u5171\u6570\u636e\u6846\u67b6&#xff1a;\u6574\u5408 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