{"id":121454,"date":"2026-11-02T21:17:47","date_gmt":"2026-11-02T13:17:47","guid":{"rendered":"https:\/\/www.wsisp.com\/helps\/121454.html"},"modified":"2026-11-02T21:17:47","modified_gmt":"2026-11-02T13:17:47","slug":"%e7%bb%86%e8%83%9e%e6%9c%89%e4%ba%94%e7%a7%8d%e6%ad%bb%e6%b3%95%ef%bc%8c%e7%99%8c%e7%bb%86%e8%83%9e%e6%9c%80%e6%80%95%e7%9a%84%e6%98%af%e5%93%aa%e4%b8%80%e7%a7%8d%ef%bc%9f-info-x-me","status":"publish","type":"post","link":"https:\/\/www.wsisp.com\/helps\/121454.html","title":{"rendered":"\u7ec6\u80de\u6709\u4e94\u79cd\u201c\u6b7b\u6cd5\u201d\uff0c\u764c\u7ec6\u80de\u6700\u6015\u7684\u662f\u54ea\u4e00\u79cd\uff1f| Info X Med\u6587\u732e\u6df1\u5ea6\u89e3\u8bfb"},"content":{"rendered":"

\u6587\u732e\u6765\u6e90：Info X Med\u671f\u520a\u300aNature Reviews Molecular Cell Biology\u300b（Review）<\/p>\n

DOI：10.1038\/s41580-023-00689-6<\/p>\n

\u7ed3\u8bba\u5148\u884c： \u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u4e0d\u662f\u4e00\u79cd，\u800c\u662f\u81f3\u5c11\u4e09\u79cd：\u51cb\u4ea1\u3001\u7126\u4ea1\u3001\u574f\u6b7b\u6027\u51cb\u4ea1，\u5404\u81ea\u6709\u4e13\u5c5e\u7684\u201c\u6267\u884c\u673a\u5668\u201d，\u5374\u5171\u7528\u4e00\u5957 caspase \u8bed\u8a00\u3002\u51cb\u4ea1\u9760 caspase \u7ea7\u8054\u628a\u7ec6\u80de\u62c6\u89e3；\u7126\u4ea1\u9760 caspase \u5207\u5272 gasdermin \u5728\u819c\u4e0a\u6253\u5b54；\u574f\u6b7b\u6027\u51cb\u4ea1\u7531 RIPK3\/MLKL \u6267\u884c，\u5e76\u88ab caspase-8 \u5bf9 RIPK1 \u7684\u5207\u5272\u6240\u6291\u5236\u2014\u2014\u4e09\u8005\u4e4b\u95f4\u5b58\u5728\u201c\u8c01\u5148\u542f\u52a8\u8c01\u5c31\u538b\u5236\u53e6\u5916\u4e24\u4e2a\u201d\u7684\u4e92\u65a5\u5173\u7cfb\u3002\u6b64\u5916，\u79bb\u5b50\u5931\u8861\u3001\u6c27\u5316\u8fd8\u539f\u5d29\u6e83\u3001\u6eb6\u9176\u4f53\u901a\u91cf\u53d7\u963b\u7b49\u201c\u7a33\u6001\u7834\u574f\u201d\u4e5f\u80fd\u6740\u6b7b\u7ec6\u80de，\u5374\u4e0d\u8d70\u7a0b\u5e8f\u6027\u901a\u8def\u3002\u7406\u89e3\u8fd9\u5957\u5206\u5de5，\u624d\u80fd\u89e3\u91ca\u4e3a\u4ec0\u4e48\u6291\u5236\u4e00\u79cd\u6b7b\u4ea1\u6709\u65f6\u53cd\u800c\u8ba9\u53e6\u4e00\u79cd\u66f4\u51f6\u3002<\/p>\n

\u4e00\u3001\u4e09\u79cd\u201c\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u201d\u7684\u5206\u5de5<\/span><\/span><\/h3>\n
    \n
  • \u7a0b\u5e8f\u6027\u6b7b\u4ea1（programmed cell death）\u6307\u7684\u662f\u7531\u4e13\u95e8\u5206\u5b50\u673a\u5668\u6267\u884c\u7684\u3001\u53ef\u8c03\u63a7\u7684\u6b7b\u4ea1，\u4e0e\u201c\u610f\u5916\u574f\u6b7b\u201d\u76f8\u5bf9\u3002<\/li>\n
  • \u51cb\u4ea1（apoptosis）：\u6700\u7ecf\u5178\u3001\u6700\u201c\u5e72\u51c0\u201d\u7684\u6b7b\u6cd5，\u7ec6\u80de\u76b1\u7f29\u3001\u51fa\u6ce1\u3001\u88ab\u90bb\u8fd1\u7ec6\u80de\u6216\u5de8\u566c\u7ec6\u80de\u541e\u566c，\u4e0d\u5f15\u53d1\u708e\u75c7\u3002<\/li>\n
  • \u7126\u4ea1（pyroptosis）：\u4f34\u968f\u5f3a\u70c8\u708e\u75c7\u7684\u6b7b\u4ea1，\u662f\u5bbf\u4e3b\u5bf9\u6297\u80de\u5185\u75c5\u539f\u4f53\u7684\u91cd\u8981\u6b66\u5668\u3002<\/li>\n
  • \u574f\u6b7b\u6027\u51cb\u4ea1（necroptosis）：\u5f62\u6001\u4e0a\u50cf\u574f\u6b7b\u3001\u673a\u5236\u4e0a\u5374\u9ad8\u5ea6\u53ef\u63a7，\u662f\u51cb\u4ea1\u88ab\u963b\u65ad\u65f6\u7684\u201c\u5907\u7528\u65b9\u6848\u201d\u3002<\/li>\n
  • \u5927\u767d\u8bdd：\u51cb\u4ea1\u50cf\u201c\u6084\u6084\u9000\u573a\u201d，\u7126\u4ea1\u50cf\u201c\u62c9\u54cd\u8b66\u62a5\u540c\u5f52\u4e8e\u5c3d\u201d，\u574f\u6b7b\u6027\u51cb\u4ea1\u50cf\u201c\u9000\u573a\u901a\u9053\u88ab\u5835\u6b7b\u540e，\u7838\u5899\u51fa\u53bb\u201d\u3002<\/li>\n<\/ul>\n

    \u4e8c\u3001\u51cb\u4ea1：caspase \u7ea7\u8054\u7684\u201c\u6d41\u6c34\u7ebf\u201d<\/span><\/span><\/h3>\n
      \n
    • \u8d77\u59cb caspase（\u5982 caspase-8\u3001caspase-9）\u88ab\u6fc0\u6d3b\u540e，\u5207\u5272\u6267\u884c caspase（caspase-3\u30017），\u540e\u8005\u518d\u53bb\u5207\u5272\u6570\u767e\u79cd\u5e95\u7269\u3002<\/li>\n
    • \u8fd9\u6761\u7ea7\u8054\u7684\u540e\u679c\u662f\u9ad8\u5ea6\u6709\u5e8f\u7684：\u7ec6\u80de\u9aa8\u67b6\u89e3\u4f53\u3001DNA \u88ab\u5207\u5272\u6210\u7247\u6bb5\u3001\u78f7\u8102\u9170\u4e1d\u6c28\u9178\u5916\u7ffb\u6210\u4e3a\u201c\u5403\u6211\u201d\u4fe1\u53f7\u3002<\/li>\n
    • \u51cb\u4ea1\u7684\u4e24\u6761\u4e3b\u901a\u8def：\u5916\u6e90\u6027（\u6b7b\u4ea1\u53d7\u4f53\u2192caspase-8）\u4e0e\u5185\u6e90\u6027（\u7ebf\u7c92\u4f53\u5916\u819c\u901a\u900f\u5316\u2192\u7ec6\u80de\u8272\u7d20 c \u91ca\u653e\u2192\u51cb\u4ea1\u4f53\u2192caspase-9）\u3002<\/li>\n
    • BCL-2 \u5bb6\u65cf\u662f\u5185\u6e90\u6027\u901a\u8def\u7684\u201c\u95f8\u95e8\u201d：\u4fc3\u51cb\u4ea1\u6210\u5458（BAX\/BAK）\u6253\u5f00\u95f8\u95e8，\u6297\u51cb\u4ea1\u6210\u5458（BCL-2\u3001MCL1）\u628a\u95f8\u95e8\u6309\u4f4f\u3002<\/li>\n
    • \u5927\u767d\u8bdd：\u51cb\u4ea1\u4e0d\u662f\u201c\u7ec6\u80de\u7206\u70b8\u201d，\u800c\u662f\u4e00\u573a\u6309\u5267\u672c\u6267\u884c\u7684\u201c\u6709\u5e8f\u62c6\u9664\u201d\u2014\u2014\u5148\u65ad\u7535\u3001\u518d\u62c6\u5899\u3001\u6700\u540e\u628a\u5783\u573e\u6253\u5305\u597d\u7b49\u4eba\u6765\u6536\u3002<\/li>\n<\/ul>\n

      \u4e09\u3001\u7126\u4ea1：gasdermin \u5728\u819c\u4e0a\u201c\u6253\u5b54\u201d<\/span><\/span><\/h3>\n
        \n
      • \u7126\u4ea1\u7684\u5173\u952e\u4e0d\u662f caspase \u672c\u8eab，\u800c\u662f\u5b83\u7684\u5e95\u7269\u2014\u2014gasdermin \u5bb6\u65cf\u86cb\u767d（GSDMD\u3001GSDME \u7b49）\u3002<\/li>\n
      • \u9759\u606f\u72b6\u6001\u4e0b，gasdermin \u7684\u6210\u5b54\u7ed3\u6784\u57df\u88ab\u81ea\u6291\u5236\u7ed3\u6784\u57df\u201c\u9501\u4f4f\u201d；caspase \u5207\u5272\u540e，\u6291\u5236\u89e3\u9664，\u6210\u5b54\u57df\u63d2\u5165\u819c\u4e2d\u805a\u5408\u6210\u5b54\u3002<\/li>\n
      • \u5b54\u4e00\u65e6\u5f62\u6210，\u7ec6\u80de\u5185\u5916\u79bb\u5b50\u5931\u8861\u3001\u5185\u5bb9\u7269\u91ca\u653e，IL-1\u03b2\u3001IL-18 \u7b49\u708e\u75c7\u56e0\u5b50\u88ab\u91ca\u653e，\u5f3a\u70c8\u62db\u52df\u514d\u75ab\u7ec6\u80de\u3002<\/li>\n
      • \u6240\u4ee5\u7126\u4ea1\u65e2\u662f\u201c\u6740\u83cc\u624b\u6bb5\u201d，\u4e5f\u662f\u201c\u708e\u75c7\u653e\u5927\u5668\u201d\u2014\u2014\u8fd9\u4e5f\u89e3\u91ca\u4e86\u4e3a\u4ec0\u4e48\u5b83\u65e2\u6297\u611f\u67d3\u3001\u53c8\u80fd\u5728\u8d25\u8840\u75c7\u4e2d\u9020\u6210\u635f\u4f24\u3002<\/li>\n
      • \u5927\u767d\u8bdd：\u7126\u4ea1\u7684\u5206\u5b50\u903b\u8f91\u7279\u522b\u76f4\u767d：caspase \u662f\u526a\u5200，gasdermin \u662f\u201c\u88ab\u526a\u5f00\u624d\u4f1a\u6253\u5b54\u201d\u7684\u5f39\u7c27\u5200\u3002\u526a\u4e00\u4e0b，\u5200\u5c31\u5f39\u51fa\u6765，\u819c\u4e0a\u591a\u4e00\u4e2a\u6d1e\u3002<\/li>\n<\/ul>\n

        \u56db\u3001\u574f\u6b7b\u6027\u51cb\u4ea1：RIPK3\/MLKL \u4e0e caspase-8 \u7684\u201c\u5239\u8f66\u201d<\/span><\/span><\/h3>\n
          \n
        • \u5f53\u51cb\u4ea1\u901a\u8def\u88ab\u963b\u65ad（\u4f8b\u5982 caspase-8 \u53d7\u6291\u5236），RIPK1 \u4e0e RIPK3 \u5f62\u6210\u574f\u6b7b\u4f53，RIPK3 \u78f7\u9178\u5316 MLKL\u3002<\/li>\n
        • \u78f7\u9178\u5316\u7684 MLKL \u8f6c\u4f4d\u5230\u7ec6\u80de\u819c，\u5f62\u6210\u5b54\u9053\u6216\u6539\u53d8\u819c\u5b8c\u6574\u6027，\u5bfc\u81f4\u574f\u6b7b\u6837\u6b7b\u4ea1\u5e76\u91ca\u653e DAMPs\u3002<\/li>\n
        • \u5173\u952e\u8c03\u63a7\u70b9：caspase-8 \u80fd\u5207\u5272 RIPK1，\u4ece\u800c\u201c\u5173\u6389\u201d\u574f\u6b7b\u6027\u51cb\u4ea1\u2014\u2014\u8fd9\u89e3\u91ca\u4e86\u4e3a\u4ec0\u4e48 caspase \u6291\u5236\u5242\u6709\u65f6\u4e0d\u4fdd\u62a4\u7ec6\u80de，\u53cd\u800c\u8ba9\u7ec6\u80de\u4ee5\u574f\u6b7b\u6027\u51cb\u4ea1\u7684\u65b9\u5f0f\u6b7b\u6389\u3002<\/li>\n
        • \u8fd9\u6761\u901a\u8def\u5728\u6297\u75c5\u6bd2\u9632\u5fa1\u3001\u708e\u75c7\u6027\u75be\u75c5\u4e0e\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u4e2d\u90fd\u6709\u91cd\u8981\u4f5c\u7528\u3002<\/li>\n
        • \u5927\u767d\u8bdd：\u8fd9\u4e09\u79cd\u6b7b\u4ea1\u4e0d\u662f\u4e09\u6761\u5e73\u884c\u7ebf，\u800c\u662f\u4e00\u5f20\u201c\u4e92\u9501\u7535\u8def\u201d：\u51cb\u4ea1\u5f00\u7740，\u574f\u6b7b\u6027\u51cb\u4ea1\u5c31\u5173\u7740；\u628a\u51cb\u4ea1\u7684\u5f00\u5173\u63b0\u65ad，\u53e6\u4e00\u6761\u7ebf\u5c31\u81ea\u52a8\u63a5\u901a\u3002<\/li>\n<\/ul>\n

          \u4e94\u3001\u4e0d\u8d70\u7a0b\u5e8f\u7684\u8def：\u7a33\u6001\u5d29\u6e83\u5982\u4f55\u6740\u6b7b\u7ec6\u80de<\/span><\/span><\/h3>\n
            \n
          • \u9664\u4e86\u4e0a\u8ff0\u4e09\u79cd，\u7ec6\u80de\u8fd8\u53ef\u4ee5\u56e0\u4e3a\u201c\u7ef4\u6301\u751f\u5b58\u7684\u57fa\u672c\u673a\u5236\u88ab\u7834\u574f\u201d\u800c\u6b7b\u4ea1，\u4e0d\u9700\u8981\u542f\u52a8\u4e13\u95e8\u7684\u6b7b\u4ea1\u673a\u5668\u3002<\/li>\n
          • \u5174\u594b\u6027\u6bd2\u6027（excitotoxicity）：\u8c37\u6c28\u9178\u53d7\u4f53\u8fc7\u5ea6\u6fc0\u6d3b\u2192\u9499\u8d85\u8f7d\u2192\u7ebf\u7c92\u4f53\u635f\u4f24\u4e0e\u86cb\u767d\u9176\u6fc0\u6d3b，\u89c1\u4e8e\u5352\u4e2d\u4e0e\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u3002<\/li>\n
          • \u94c1\u6b7b\u4ea1（ferroptosis）：\u94c1\u4f9d\u8d56\u7684\u819c\u8102\u8d28\u8fc7\u6c27\u5316，\u4e0e\u534a\u80f1\u6c28\u9178\/\u8c37\u80f1\u7518\u80bd\u4ee3\u8c22\u3001GPX4 \u6d3b\u6027\u5bc6\u5207\u76f8\u5173\u3002<\/li>\n
          • \u6eb6\u9176\u4f53\u7ec6\u80de\u6b7b\u4ea1：\u6eb6\u9176\u4f53\u819c\u901a\u900f\u5316\u540e，\u7ec4\u7ec7\u86cb\u767d\u9176\u6cc4\u6f0f\u5230\u80de\u8d28，\u89e6\u53d1\u6b7b\u4ea1\u3002<\/li>\n
          • \u79bb\u5b50\u7a33\u6001（\u94be\u3001\u9499\u3001\u6c2f）\u4e0e\u6c27\u5316\u8fd8\u539f\u5e73\u8861\u7684\u7834\u574f，\u672c\u8eab\u5c31\u53ef\u4ee5\u662f\u201c\u6b7b\u4ea1\u6267\u884c\u6b65\u9aa4\u201d\u3002<\/li>\n
          • \u5927\u767d\u8bdd：\u8fd9\u4e00\u7c7b\u6b7b\u4ea1\u66f4\u50cf\u201c\u623f\u5b50\u584c\u4e86\u201d，\u800c\u4e0d\u662f\u201c\u6309\u5267\u672c\u62c6\u7684\u201d\u3002\u533a\u522b\u5f88\u91cd\u8981\u2014\u2014\u524d\u8005\u96be\u4ee5\u7528\u201c\u6291\u5236\u67d0\u4e2a\u6b7b\u4ea1\u86cb\u767d\u201d\u6765\u963b\u6b62，\u53ea\u80fd\u4fee\u623f\u5b50（\u6062\u590d\u7a33\u6001）\u3002<\/li>\n<\/ul>\n

            \"\"<\/p>\n

            \u56fe1\u3000\u51cb\u4ea1\u901a\u8def\u7684\u6838\u5fc3\u8282\u70b9（\u539f\u6587 Fig 1）<\/span><\/p>\n

            （\u8bfb\u56fe：\u4ece\u6b7b\u4ea1\u53d7\u4f53（TNFR\u3001FAS）\u4e0e\u7ebf\u7c92\u4f53\u4e24\u6761\u4e0a\u6e38\u901a\u8def，\u6c47\u805a\u5230 caspase-8\/9 \u7684\u6fc0\u6d3b，\u518d\u653e\u5927\u4e3a caspase-3\/7 \u7684\u6267\u884c；\u53f3\u4fa7\u6807\u51fa\u4e86 BCL-2 \u5bb6\u65cf\u4e0e IAP \u5bb6\u65cf\u8fd9\u4e24\u9053\u201c\u95f8\u95e8\u201d\u3002）<\/p>\n

            \u516d\u3001\u6cbb\u7597：\u6740\u764c\u7ec6\u80de，\u8fd8\u662f\u4fdd\u795e\u7ecf\u5143？<\/span><\/span><\/h3>\n
              \n
            • \u6297\u764c\u601d\u8def\u4e00：\u76f4\u63a5\u8bf1\u5bfc\u51cb\u4ea1（BCL-2 \u6291\u5236\u5242\u3001SMAC \u6a21\u62df\u7269）\u3002<\/li>\n
            • \u6297\u764c\u601d\u8def\u4e8c：\u8bf1\u5bfc\u201c\u975e\u51cb\u4ea1\u201d\u6b7b\u4ea1\u2014\u2014\u94c1\u6b7b\u4ea1\u3001\u7126\u4ea1\u3001\u574f\u6b7b\u6027\u51cb\u4ea1，\u7528\u6765\u5bf9\u4ed8\u51cb\u4ea1\u901a\u8def\u5931\u6d3b\u7684\u80bf\u7624\u3002<\/li>\n
            • \u6297\u764c\u601d\u8def\u4e09（\u6587\u7ae0\u5f3a\u8c03\u7684\u65b0\u65b9\u5411）：\u4e0d\u53bb\u201c\u52a0\u6b7b\u4ea1\u4fe1\u53f7\u201d，\u800c\u662f\u201c\u62c6\u6389\u764c\u7ec6\u80de\u8d56\u4ee5\u751f\u5b58\u7684\u7a33\u6001\u673a\u5236\u201d，\u8ba9\u5b83\u81ea\u5df1\u5d29\u6389\u3002<\/li>\n
            • \u4fdd\u62a4\u6027\u601d\u8def：\u5728\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u3001\u7cd6\u5c3f\u75c5\u4e2d，\u589e\u5f3a\u7279\u5b9a\u7684\u4fc3\u5b58\u6d3b\u673a\u5236（\u800c\u975e\u6cdb\u6cdb\u5730\u201c\u6297\u51cb\u4ea1\u201d），\u53ef\u80fd\u6bd4\u963b\u65ad\u6b7b\u4ea1\u901a\u8def\u66f4\u6709\u6548\u3002<\/li>\n
            • \u6587\u7ae0\u7279\u522b\u63d0\u5230：\u5728\u7f3a\u8840\u3001\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e2d，\u6062\u590d\u88ab\u7834\u574f\u7684\u5b58\u6d3b\u4fe1\u53f7，\u6216\u8bb8\u80fd\u8ba9\u795e\u7ecf\u5143\u6216\u80f0\u5c9b \u03b2 \u7ec6\u80de\u201c\u5728\u6076\u52a3\u73af\u5883\u91cc\u6d3b\u4e0b\u6765\u201d\u3002<\/li>\n
            • \u5927\u767d\u8bdd：\u8fc7\u53bb\u4e8c\u5341\u5e74，\u836f\u7269\u7814\u53d1\u51e0\u4e4e\u90fd\u5728\u201c\u5835\u6b7b\u4ea1\u901a\u8def\u201d；\u8fd9\u7bc7\u6587\u7ae0\u63d0\u9192，\u53e6\u4e00\u6761\u8def\u540c\u6837\u6210\u7acb\u2014\u2014\u628a\u7ec6\u80de\u8d56\u4ee5\u6d3b\u547d\u7684\u201c\u652f\u67b6\u201d\u4fee\u597d\u3002\u524d\u8005\u662f\u5173\u6389\u67aa，\u540e\u8005\u662f\u7ed9\u7ec6\u80de\u7a7f\u9632\u5f39\u8863\u3002<\/li>\n<\/ul>\n

              \u4e03\u3001\u4e00\u53e5\u8bdd\u603b\u7ed3<\/span><\/span><\/h3>\n

              \u7a0b\u5e8f\u6027\u6b7b\u4ea1\u81f3\u5c11\u6709\u51cb\u4ea1\u3001\u7126\u4ea1\u3001\u574f\u6b7b\u6027\u51cb\u4ea1\u4e09\u6761\u4e3b\u8def，\u5b83\u4eec\u5171\u7528 caspase \u8bed\u8a00\u5374\u5f7c\u6b64\u4e92\u9501；\u800c\u79bb\u5b50\u3001\u6c27\u5316\u8fd8\u539f\u3001\u6eb6\u9176\u4f53\u7b49\u7a33\u6001\u673a\u5236\u7684\u5d29\u6e83，\u5219\u63d0\u4f9b\u4e86\u53e6\u4e00\u7c7b\u201c\u975e\u7a0b\u5e8f\u6027\u201d\u7684\u6b7b\u6cd5\u2014\u2014\u7406\u89e3\u8fd9\u5957\u5206\u5de5，\u624d\u8c08\u5f97\u4e0a\u201c\u8be5\u6740\u7684\u65f6\u5019\u6740\u5f97\u51c6，\u8be5\u4fdd\u7684\u65f6\u5019\u4fdd\u5f97\u4f4f\u201d\u3002<\/p>\n

              \u8fd9\u7bc7\u6587\u7ae0\u6700\u5b9e\u7528\u7684\u63d0\u9192，\u662f\u201c\u4e92\u9501\u201d\u4e8c\u5b57：\u6291\u5236 caspase \u5e76\u4e0d\u7b49\u4e8e\u4fdd\u4f4f\u7ec6\u80de，\u56e0\u4e3a caspase-8 \u540c\u65f6\u662f\u574f\u6b7b\u6027\u51cb\u4ea1\u7684\u5239\u8f66；\u963b\u65ad\u4e00\u6761\u6b7b\u4ea1\u901a\u8def，\u7ec6\u80de\u53ef\u80fd\u4ece\u53e6\u4e00\u6761\u8def\u6b7b\u5f97\u66f4\u54cd\u3002\u8fd9\u5bf9\u836f\u7269\u5f00\u53d1\u662f\u76f4\u63a5\u7684\u8b66\u793a\u2014\u2014\u5355\u9776\u70b9\u7684\u201c\u6297\u51cb\u4ea1\u201d\u7b56\u7565，\u5fc5\u987b\u540c\u65f6\u8bc4\u4f30\u5176\u4ed6\u6b7b\u4ea1\u901a\u8def\u7684\u4ee3\u507f\u3002\u53cd\u8fc7\u6765，\u5bf9\u80bf\u7624\u6cbb\u7597，\u8fd9\u79cd\u5197\u4f59\u6070\u6070\u662f\u673a\u4f1a：\u5f53\u51cb\u4ea1\u901a\u8def\u5931\u6d3b\u65f6，\u94c1\u6b7b\u4ea1\u4e0e\u7126\u4ea1\u5c31\u6210\u4e86\u53ef\u7528\u7684\u201c\u5907\u7528\u5f00\u5173\u201d\u3002<\/p>\n

              \u514d\u8d23\u58f0\u660e： \u672c\u6587\u4e3a\u6587\u732e\u89e3\u8bfb\u4e0e\u79d1\u666e，\u4e0d\u6784\u6210\u4efb\u4f55\u8bca\u7597\u5efa\u8bae\u3002<\/p>\n

              \u5728Info X Med\u5373\u53ef\u67e5\u770b\u539f\u6587\u732e<\/p>\n

              \u6807\u7b7e： `#\u7ec6\u80de\u6b7b\u4ea1` `#\u51cb\u4ea1` `#\u7126\u4ea1` `#\u574f\u6b7b\u6027\u51cb\u4ea1` `#caspase` `#gasdermin` `#\u6587\u732e\u89e3\u8bfb`<\/p>\n","protected":false},"excerpt":{"rendered":"

              \u6587\u732e\u6765\u6e90：Info X Med\u671f\u520a\u300aNature Reviews Molecular Cell Biology\u300b（Review）DOI：10.1038\/s41580-023-00689-6\u7ed3\u8bba\u5148\u884c： \u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u4e0d\u662f\u4e00\u79cd，\u800c\u662f\u81f3\u5c11\u4e09\u79cd：\u51cb\u4ea1\u3001\u7126\u4ea1\u3001\u574f\u6b7b\u6027\u51cb\u4ea1，\u5404\u81ea\u6709\u4e13\u5c5e\u7684\u201c\u6267\u884c\u673a\u5668\u201d，\u5374\u5171\u7528\u4e00\u5957 caspase \u8bed\u8a00\u3002\u51cb\u4ea1\u9760 caspase \u7ea7\u8054\u628a\u7ec6<\/p>\n","protected":false},"author":2,"featured_media":121453,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[13613,13899,13614,13900,13898],"topic":[],"class_list":["post-121454","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-server","tag-info-x-med","tag-13899","tag-13614","tag-13900","tag-13898"],"yoast_head":"\n\u7ec6\u80de\u6709\u4e94\u79cd\u201c\u6b7b\u6cd5\u201d\uff0c\u764c\u7ec6\u80de\u6700\u6015\u7684\u662f\u54ea\u4e00\u79cd\uff1f| Info X Med\u6587\u732e\u6df1\u5ea6\u89e3\u8bfb - \u7f51\u7855\u4e92\u8054\u5e2e\u52a9\u4e2d\u5fc3<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.wsisp.com\/helps\/121454.html\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u7ec6\u80de\u6709\u4e94\u79cd\u201c\u6b7b\u6cd5\u201d\uff0c\u764c\u7ec6\u80de\u6700\u6015\u7684\u662f\u54ea\u4e00\u79cd\uff1f| Info X Med\u6587\u732e\u6df1\u5ea6\u89e3\u8bfb - \u7f51\u7855\u4e92\u8054\u5e2e\u52a9\u4e2d\u5fc3\" \/>\n<meta property=\"og:description\" content=\"\u6587\u732e\u6765\u6e90：Info X Med\u671f\u520a\u300aNature Reviews Molecular Cell Biology\u300b（Review）DOI：10.1038\/s41580-023-00689-6\u7ed3\u8bba\u5148\u884c： \u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u4e0d\u662f\u4e00\u79cd，\u800c\u662f\u81f3\u5c11\u4e09\u79cd：\u51cb\u4ea1\u3001\u7126\u4ea1\u3001\u574f\u6b7b\u6027\u51cb\u4ea1，\u5404\u81ea\u6709\u4e13\u5c5e\u7684\u201c\u6267\u884c\u673a\u5668\u201d，\u5374\u5171\u7528\u4e00\u5957 caspase \u8bed\u8a00\u3002\u51cb\u4ea1\u9760 caspase \u7ea7\u8054\u628a\u7ec6\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.wsisp.com\/helps\/121454.html\" \/>\n<meta property=\"og:site_name\" content=\"\u7f51\u7855\u4e92\u8054\u5e2e\u52a9\u4e2d\u5fc3\" \/>\n<meta property=\"article:published_time\" content=\"2026-11-02T13:17:47+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/11\/20261102131746-6ae88d7a68521.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u4f5c\u8005\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u9884\u8ba1\u9605\u8bfb\u65f6\u95f4\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 \u5206\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.wsisp.com\/helps\/121454.html\",\"url\":\"https:\/\/www.wsisp.com\/helps\/121454.html\",\"name\":\"\u7ec6\u80de\u6709\u4e94\u79cd\u201c\u6b7b\u6cd5\u201d\uff0c\u764c\u7ec6\u80de\u6700\u6015\u7684\u662f\u54ea\u4e00\u79cd\uff1f| Info X Med\u6587\u732e\u6df1\u5ea6\u89e3\u8bfb - \u7f51\u7855\u4e92\u8054\u5e2e\u52a9\u4e2d\u5fc3\",\"isPartOf\":{\"@id\":\"https:\/\/www.wsisp.com\/helps\/#website\"},\"datePublished\":\"2026-11-02T13:17:47+00:00\",\"dateModified\":\"2026-11-02T13:17:47+00:00\",\"author\":{\"@id\":\"https:\/\/www.wsisp.com\/helps\/#\/schema\/person\/358e386c577a3ab51c4493330a20ad41\"},\"breadcrumb\":{\"@id\":\"https:\/\/www.wsisp.com\/helps\/121454.html#breadcrumb\"},\"inLanguage\":\"zh-Hans\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.wsisp.com\/helps\/121454.html\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.wsisp.com\/helps\/121454.html#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.wsisp.com\/helps\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u7ec6\u80de\u6709\u4e94\u79cd\u201c\u6b7b\u6cd5\u201d\uff0c\u764c\u7ec6\u80de\u6700\u6015\u7684\u662f\u54ea\u4e00\u79cd\uff1f| Info X Med\u6587\u732e\u6df1\u5ea6\u89e3\u8bfb\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.wsisp.com\/helps\/#website\",\"url\":\"https:\/\/www.wsisp.com\/helps\/\",\"name\":\"\u7f51\u7855\u4e92\u8054\u5e2e\u52a9\u4e2d\u5fc3\",\"description\":\"\u9999\u6e2f\u670d\u52a1\u5668_\u9999\u6e2f\u4e91\u670d\u52a1\u5668\u8d44\u8baf_\u670d\u52a1\u5668\u5e2e\u52a9\u6587\u6863_\u670d\u52a1\u5668\u6559\u7a0b\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.wsisp.com\/helps\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"zh-Hans\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.wsisp.com\/helps\/#\/schema\/person\/358e386c577a3ab51c4493330a20ad41\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-Hans\",\"@id\":\"https:\/\/www.wsisp.com\/helps\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/gravatar.wp-china-yes.net\/avatar\/?s=96&d=mystery\",\"contentUrl\":\"https:\/\/gravatar.wp-china-yes.net\/avatar\/?s=96&d=mystery\",\"caption\":\"admin\"},\"sameAs\":[\"http:\/\/wp.wsisp.com\"],\"url\":\"https:\/\/www.wsisp.com\/helps\/author\/admin\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u7ec6\u80de\u6709\u4e94\u79cd\u201c\u6b7b\u6cd5\u201d\uff0c\u764c\u7ec6\u80de\u6700\u6015\u7684\u662f\u54ea\u4e00\u79cd\uff1f| Info X Med\u6587\u732e\u6df1\u5ea6\u89e3\u8bfb - \u7f51\u7855\u4e92\u8054\u5e2e\u52a9\u4e2d\u5fc3","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.wsisp.com\/helps\/121454.html","og_locale":"zh_CN","og_type":"article","og_title":"\u7ec6\u80de\u6709\u4e94\u79cd\u201c\u6b7b\u6cd5\u201d\uff0c\u764c\u7ec6\u80de\u6700\u6015\u7684\u662f\u54ea\u4e00\u79cd\uff1f| Info X Med\u6587\u732e\u6df1\u5ea6\u89e3\u8bfb - \u7f51\u7855\u4e92\u8054\u5e2e\u52a9\u4e2d\u5fc3","og_description":"\u6587\u732e\u6765\u6e90：Info X Med\u671f\u520a\u300aNature Reviews Molecular Cell Biology\u300b（Review）DOI：10.1038\/s41580-023-00689-6\u7ed3\u8bba\u5148\u884c： \u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u4e0d\u662f\u4e00\u79cd，\u800c\u662f\u81f3\u5c11\u4e09\u79cd：\u51cb\u4ea1\u3001\u7126\u4ea1\u3001\u574f\u6b7b\u6027\u51cb\u4ea1，\u5404\u81ea\u6709\u4e13\u5c5e\u7684\u201c\u6267\u884c\u673a\u5668\u201d，\u5374\u5171\u7528\u4e00\u5957 caspase \u8bed\u8a00\u3002\u51cb\u4ea1\u9760 caspase \u7ea7\u8054\u628a\u7ec6","og_url":"https:\/\/www.wsisp.com\/helps\/121454.html","og_site_name":"\u7f51\u7855\u4e92\u8054\u5e2e\u52a9\u4e2d\u5fc3","article_published_time":"2026-11-02T13:17:47+00:00","og_image":[{"url":"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/11\/20261102131746-6ae88d7a68521.jpg"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"\u4f5c\u8005":"admin","\u9884\u8ba1\u9605\u8bfb\u65f6\u95f4":"2 \u5206"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.wsisp.com\/helps\/121454.html","url":"https:\/\/www.wsisp.com\/helps\/121454.html","name":"\u7ec6\u80de\u6709\u4e94\u79cd\u201c\u6b7b\u6cd5\u201d\uff0c\u764c\u7ec6\u80de\u6700\u6015\u7684\u662f\u54ea\u4e00\u79cd\uff1f| Info X Med\u6587\u732e\u6df1\u5ea6\u89e3\u8bfb - \u7f51\u7855\u4e92\u8054\u5e2e\u52a9\u4e2d\u5fc3","isPartOf":{"@id":"https:\/\/www.wsisp.com\/helps\/#website"},"datePublished":"2026-11-02T13:17:47+00:00","dateModified":"2026-11-02T13:17:47+00:00","author":{"@id":"https:\/\/www.wsisp.com\/helps\/#\/schema\/person\/358e386c577a3ab51c4493330a20ad41"},"breadcrumb":{"@id":"https:\/\/www.wsisp.com\/helps\/121454.html#breadcrumb"},"inLanguage":"zh-Hans","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.wsisp.com\/helps\/121454.html"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.wsisp.com\/helps\/121454.html#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"https:\/\/www.wsisp.com\/helps"},{"@type":"ListItem","position":2,"name":"\u7ec6\u80de\u6709\u4e94\u79cd\u201c\u6b7b\u6cd5\u201d\uff0c\u764c\u7ec6\u80de\u6700\u6015\u7684\u662f\u54ea\u4e00\u79cd\uff1f| Info X Med\u6587\u732e\u6df1\u5ea6\u89e3\u8bfb"}]},{"@type":"WebSite","@id":"https:\/\/www.wsisp.com\/helps\/#website","url":"https:\/\/www.wsisp.com\/helps\/","name":"\u7f51\u7855\u4e92\u8054\u5e2e\u52a9\u4e2d\u5fc3","description":"\u9999\u6e2f\u670d\u52a1\u5668_\u9999\u6e2f\u4e91\u670d\u52a1\u5668\u8d44\u8baf_\u670d\u52a1\u5668\u5e2e\u52a9\u6587\u6863_\u670d\u52a1\u5668\u6559\u7a0b","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.wsisp.com\/helps\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"zh-Hans"},{"@type":"Person","@id":"https:\/\/www.wsisp.com\/helps\/#\/schema\/person\/358e386c577a3ab51c4493330a20ad41","name":"admin","image":{"@type":"ImageObject","inLanguage":"zh-Hans","@id":"https:\/\/www.wsisp.com\/helps\/#\/schema\/person\/image\/","url":"https:\/\/gravatar.wp-china-yes.net\/avatar\/?s=96&d=mystery","contentUrl":"https:\/\/gravatar.wp-china-yes.net\/avatar\/?s=96&d=mystery","caption":"admin"},"sameAs":["http:\/\/wp.wsisp.com"],"url":"https:\/\/www.wsisp.com\/helps\/author\/admin"}]}},"_links":{"self":[{"href":"https:\/\/www.wsisp.com\/helps\/wp-json\/wp\/v2\/posts\/121454","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wsisp.com\/helps\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wsisp.com\/helps\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wsisp.com\/helps\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wsisp.com\/helps\/wp-json\/wp\/v2\/comments?post=121454"}],"version-history":[{"count":0,"href":"https:\/\/www.wsisp.com\/helps\/wp-json\/wp\/v2\/posts\/121454\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.wsisp.com\/helps\/wp-json\/wp\/v2\/media\/121453"}],"wp:attachment":[{"href":"https:\/\/www.wsisp.com\/helps\/wp-json\/wp\/v2\/media?parent=121454"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wsisp.com\/helps\/wp-json\/wp\/v2\/categories?post=121454"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wsisp.com\/helps\/wp-json\/wp\/v2\/tags?post=121454"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/www.wsisp.com\/helps\/wp-json\/wp\/v2\/topic?post=121454"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}