{"id":120485,"date":"2026-10-31T19:48:31","date_gmt":"2026-10-31T11:48:31","guid":{"rendered":"https:\/\/www.wsisp.com\/helps\/120485.html"},"modified":"2026-10-31T19:48:31","modified_gmt":"2026-10-31T11:48:31","slug":"%e6%b2%a1%e6%9c%89%e5%9b%ba%e5%ae%9a%e5%bd%a2%e7%8a%b6%e7%9a%84%e8%9b%8b%e7%99%bd%ef%bc%8c%e5%8f%8d%e8%80%8c%e6%9b%b4%e4%bc%9a%e5%8a%9e%e4%ba%8b-info-x-med%e6%96%87%e7%8c%ae","status":"publish","type":"post","link":"https:\/\/www.wsisp.com\/helps\/120485.html","title":{"rendered":"\u6ca1\u6709\u56fa\u5b9a\u5f62\u72b6\u7684\u86cb\u767d\uff0c\u53cd\u800c\u66f4\u4f1a\u201c\u529e\u4e8b\u201d | Info X Med\u6587\u732e\u6df1\u5ea6\u89e3\u8bfb"},"content":{"rendered":"

\u6587\u732e\u6765\u6e90：Info X Med\u671f\u520a\u300aNature Reviews Molecular Cell Biology\u300b（Review）<\/p>\n

DOI：10.1038\/s41580-023-00673-0<\/p>\n

\u7ed3\u8bba\u5148\u884c： \u5185\u5728\u65e0\u5e8f\u533a（IDR）\u4e0d\u6298\u53e0\u6210\u5355\u4e00\u4e09\u7ef4\u7ed3\u6784，\u800c\u662f\u4ee5\u201c\u6784\u8c61\u96c6\u5408\u201d\u7684\u5f62\u5f0f\u5b58\u5728：\u4e00\u5806\u5feb\u901f\u4e92\u53d8\u7684\u6784\u8c61，\u6ca1\u6709\u54ea\u4e2a\u662f\u7a33\u5b9a\u7684\u201c\u6b63\u786e\u7b54\u6848\u201d\u3002\u5b83\u4eec\u9760\u77ed\u7ebf\u6027\u57fa\u5e8f（SLiM）\u3001\u591a\u4ef7\u76f8\u4e92\u4f5c\u7528\u4e0e\u96c6\u5408\u6027\u8d28（\u5c3a\u5bf8\u3001\u77ac\u6001\u4e8c\u7ea7\u7ed3\u6784\u3001\u7aef\u5230\u7aef\u8ddd\u79bb）\u5b9e\u73b0\u7279\u5f02\u800c\u53ef\u8c03\u7684\u8bc6\u522b\u3002\u5173\u952e\u7ed3\u8bba\u662f：IDR \u7684\u7279\u5f02\u6027\u5f80\u5f80\u4e0d\u6765\u81ea\u9ad8\u4eb2\u548c\u529b，\u800c\u6765\u81ea\u201c\u591a\u4ef7\u534f\u540c\u201d\u2014\u2014\u800c\u5f31\u7ed3\u5408\u6070\u6070\u662f\u53ef\u8c03\u63a7\u6027\u4e4b\u6240\u5728，\u8fd9\u4f7f IDR \u6210\u4e3a\u7ec6\u80de\u5185\u6700\u7075\u6d3b\u7684\u201c\u901a\u8baf\u63a5\u53e3\u201d\u3002<\/p>\n

\u4e00\u3001\u5148\u7834\u4e00\u4e2a\u504f\u89c1：\u6ca1\u6709\u7ed3\u6784 \u2260 \u6ca1\u6709\u529f\u80fd<\/span><\/span><\/h3>\n
    \n
  • \u4f20\u7edf\u7ed3\u6784\u751f\u7269\u5b66\u7684\u57fa\u672c\u5047\u8bbe\u662f\u201c\u5e8f\u5217\u2192\u7ed3\u6784\u2192\u529f\u80fd\u201d，\u800c IDR \u6070\u6070\u6253\u7834\u4e86\u4e2d\u95f4\u90a3\u4e00\u73af：\u5b83\u6709\u5e8f\u5217\u3001\u6709\u529f\u80fd，\u5374\u6ca1\u6709\u7a33\u5b9a\u7ed3\u6784\u3002<\/li>\n
  • IDR \u5728\u6240\u6709\u7269\u79cd\u4e2d\u666e\u904d\u5b58\u5728，\u5728\u771f\u6838\u751f\u7269\u4e2d\u5c24\u5176\u4e30\u5bcc\u2014\u2014\u8f6c\u5f55\u56e0\u5b50\u3001\u6838\u5b54\u86cb\u767d\u3001\u4fe1\u53f7\u63a5\u5934\u86cb\u767d\u91cc\u5230\u5904\u90fd\u662f\u3002<\/li>\n
  • \u5b83\u4eec\u7684\u529f\u80fd\u6070\u6070\u4f9d\u8d56\u201c\u4e0d\u6298\u53e0\u201d：\u4e00\u4e2a\u56fa\u5b9a\u7ed3\u6784\u53ea\u80fd\u7ed3\u5408\u4e00\u4e2a\u4f19\u4f34，\u800c\u4e00\u4e2a\u6784\u8c61\u96c6\u5408\u53ef\u4ee5\u7ed3\u5408\u591a\u4e2a\u4f19\u4f34\u3001\u5e76\u5728\u4e0d\u540c\u6761\u4ef6\u4e0b\u5207\u6362\u3002<\/li>\n
  • \u5927\u767d\u8bdd：\u6298\u53e0\u86cb\u767d\u50cf\u4e00\u628a\u4e13\u7528\u94a5\u5319，\u53ea\u5f00\u4e00\u628a\u9501；IDR \u50cf\u4e00\u5757\u6a61\u76ae\u6ce5，\u80fd\u634f\u6210\u597d\u51e0\u79cd\u5f62\u72b6，\u8fd8\u80fd\u540c\u65f6\u7c98\u4f4f\u51e0\u4e2a\u4e1c\u897f\u2014\u2014\u5728\u9700\u8981\u201c\u7075\u6d3b\u5e94\u53d8\u201d\u7684\u573a\u5408，\u6a61\u76ae\u6ce5\u66f4\u597d\u7528\u3002<\/li>\n<\/ul>\n

    \u4e8c\u3001\u96c6\u5408\u800c\u975e\u7ed3\u6784：\u600e\u4e48\u201c\u63cf\u8ff0\u201d\u4e00\u4e2a IDR<\/span><\/span><\/h3>\n
      \n
    • \u65e2\u7136\u6ca1\u6709\u5355\u4e00\u7ed3\u6784，\u5c31\u8981\u7528\u201c\u96c6\u5408\u6027\u8d28\u201d\u6765\u63cf\u8ff0：\u56de\u8f6c\u534a\u5f84（\u6574\u4f53\u6709\u591a\u8212\u5c55）\u3001\u7aef\u5230\u7aef\u8ddd\u79bb\u3001\u77ac\u6001\u4e8c\u7ea7\u7ed3\u6784\u7684\u6bd4\u4f8b\u3001\u4ee5\u53ca\u5404\u6784\u8c61\u7684\u6982\u7387\u5206\u5e03\u3002<\/li>\n
    • \u8fd9\u4e9b\u6027\u8d28\u53ef\u4ee5\u7528 NMR\u3001SAXS\u3001\u5355\u5206\u5b50 FRET\u3001\u4ee5\u53ca\u5206\u5b50\u52a8\u529b\u5b66\u6a21\u62df\u6765\u6d4b\u91cf\u6216\u63a8\u65ad\u3002<\/li>\n
    • \u540c\u4e00\u4e2a IDR \u5728\u4e0d\u540c\u6761\u4ef6\u4e0b（\u6e29\u5ea6\u3001\u79bb\u5b50\u5f3a\u5ea6\u3001\u62e5\u6324\u7a0b\u5ea6\u3001\u7ed3\u5408\u4f19\u4f34）\u4f1a\u5448\u73b0\u4e0d\u540c\u7684\u96c6\u5408\u2014\u2014\u5b83\u4e0d\u662f\u201c\u4e00\u79cd\u72b6\u6001\u201d，\u800c\u662f\u201c\u4e00\u4e2a\u72b6\u6001\u5206\u5e03\u201d\u3002<\/li>\n
    • \u5927\u767d\u8bdd：\u63cf\u8ff0\u4e00\u4e2a IDR，\u4e0d\u80fd\u95ee\u201c\u5b83\u957f\u4ec0\u4e48\u6837\u201d，\u800c\u8981\u95ee\u201c\u5b83\u6700\u53ef\u80fd\u957f\u6210\u54ea\u51e0\u79cd\u6837\u5b50\u3001\u5404\u5360\u591a\u5c11\u6bd4\u4f8b\u201d\u3002<\/li>\n<\/ul>\n

      <\/p>\n

      \u56fe1\u3000IDR \u5728\u7ec6\u80de\u5185\u7684\u529f\u80fd\u573a\u666f（\u539f\u6587\u56fe，\u8282\u9009）<\/span><\/p>\n

      （\u8bfb\u56fe：\u7ec6\u80de\u793a\u610f\u56fe\u4e0a\u7684\u865a\u7ebf\u6307\u5411\u4e0d\u540c\u7684\u529f\u80fd\u573a\u666f\u2014\u2014\u6838\u4ec1\u7ec4\u7ec7\u3001\u8f6c\u5f55\u8c03\u63a7\u7b49\u3002IDR \u7684\u4f5c\u7528\u4e0d\u662f\u201c\u5728\u67d0\u4e2a\u56fa\u5b9a\u4f4d\u7f6e\u6267\u884c\u67d0\u4e2a\u56fa\u5b9a\u53cd\u5e94\u201d，\u800c\u662f\u5728\u4e0d\u540c\u533a\u5ba4\u3001\u4e0d\u540c\u6761\u4ef6\u4e0b\u6539\u53d8\u81ea\u8eab\u7684\u96c6\u5408\u6027\u8d28，\u4ece\u800c\u5207\u6362\u529f\u80fd\u3002）<\/p>\n

      \u4e09\u3001\u5e8f\u5217\u2192\u96c6\u5408\u2192\u529f\u80fd：IDR \u7684\u201c\u8bed\u6cd5\u201d<\/span><\/span><\/h3>\n
        \n
      • IDR \u7684\u6c28\u57fa\u9178\u7ec4\u6210\u51b3\u5b9a\u4e86\u5b83\u7684\u201c\u6027\u683c\u201d：\u5e26\u7535\u6b8b\u57fa\u591a\u2192\u9ad8\u5ea6\u8212\u5c55；\u758f\u6c34\u6b8b\u57fa\u591a\u2192\u66f4\u6613\u584c\u7f29；\u812f\u6c28\u9178\u591a\u2192\u66f4\u521a\u6027\u3002<\/li>\n
      • \u51c0\u7535\u8377\u4e0e\u7535\u8377\u6392\u5e03（charge patterning）\u662f\u5173\u952e\u53c2\u6570：\u540c\u6837\u7684\u6c28\u57fa\u9178\u7ec4\u6210，\u6392\u5e03\u4e0d\u540c，\u96c6\u5408\u6027\u8d28\u53ef\u4ee5\u5b8c\u5168\u4e0d\u540c\u3002<\/li>\n
      • \u56e0\u6b64\u5b58\u5728\u4e00\u6761\u7c7b\u4f3c\u201c\u5e8f\u5217\u2192\u7ed3\u6784\u2192\u529f\u80fd\u201d\u7684\u89c4\u5f8b，\u53ea\u662f\u4e2d\u95f4\u6362\u6210\u4e86\u201c\u5e8f\u5217\u2192\u96c6\u5408\u2192\u529f\u80fd\u201d\u3002<\/li>\n
      • \u5927\u767d\u8bdd：IDR \u7684\u5e8f\u5217\u50cf\u4e00\u4efd\u201c\u914d\u65b9\u201d\u2014\u2014\u4e0d\u662f\u51b3\u5b9a\u6700\u7ec8\u5f62\u72b6，\u800c\u662f\u51b3\u5b9a\u201c\u5b83\u5728\u4ec0\u4e48\u6761\u4ef6\u4e0b\u504f\u5411\u54ea\u79cd\u5f62\u72b6\u201d\u3002\u6539\u4e00\u4e2a\u6c28\u57fa\u9178，\u53ef\u80fd\u53ea\u662f\u5fae\u8c03，\u4e5f\u53ef\u80fd\u5f7b\u5e95\u6539\u53d8\u5b83\u7684\u793e\u4ea4\u65b9\u5f0f\u3002<\/li>\n<\/ul>\n

        \u56db\u3001SLiM \u4e0e\u591a\u4ef7：\u5f31\u76f8\u4e92\u4f5c\u7528\u5982\u4f55\u53d8\u7279\u5f02<\/span><\/span><\/h3>\n
          \n
        • \u77ed\u7ebf\u6027\u57fa\u5e8f（SLiM）\u901a\u5e38\u53ea\u6709 3\u201310 \u4e2a\u6c28\u57fa\u9178，\u662f IDR \u4e0e\u4f19\u4f34\u7ed3\u5408\u7684\u6700\u5c0f\u5355\u5143\u3002<\/li>\n
        • \u5355\u4e2a SLiM \u7684\u4eb2\u548c\u529b\u5f80\u5f80\u5f88\u4f4e（\u5fae\u6469\u5c14\u5230\u6beb\u6469\u5c14\u7ea7），\u4f46\u4e00\u4e2a IDR \u4e0a\u53ef\u4ee5\u6709\u591a\u4e2a SLiM，\u901a\u8fc7\u591a\u4ef7\u7ed3\u5408\u628a\u6574\u4f53\u4eb2\u548c\u529b\u4e0e\u7279\u5f02\u6027\u201c\u4e58\u201d\u4e0a\u53bb\u3002<\/li>\n
        • \u8fd9\u79cd\u201c\u4f4e\u4eb2\u548c\u3001\u591a\u4ef7\u4f4d\u201d\u7684\u8bbe\u8ba1\u5e26\u6765\u4e24\u4e2a\u597d\u5904：\u4e00\u662f\u53ef\u9006（\u5bb9\u6613\u89e3\u5f00），\u4e8c\u662f\u53ef\u8c03（\u6539\u53d8 SLiM \u6570\u91cf\u6216\u4fee\u9970\u72b6\u6001\u5373\u53ef\u5207\u6362）\u3002<\/li>\n
        • \u75c5\u6bd2\u6b63\u662f\u5229\u7528\u8fd9\u4e00\u70b9：\u8bb8\u591a\u75c5\u6bd2\u86cb\u767d\u901a\u8fc7\u6a21\u62df\u5bbf\u4e3b SLiM \u6765\u201c\u52ab\u6301\u201d\u7ec6\u80de\u901a\u8def\u2014\u2014\u8fd9\u4ece\u53cd\u9762\u8bc1\u660e\u4e86\u5f31\u57fa\u5e8f\u4e92\u4f5c\u7684\u529f\u80fd\u91cd\u8981\u6027\u3002<\/li>\n
        • \u5927\u767d\u8bdd：\u4e00\u4e2a SLiM \u50cf\u4e00\u53e5\u6697\u53f7，\u58f0\u97f3\u5f88\u5c0f；\u4f46\u51e0\u5341\u53e5\u6697\u53f7\u4e00\u8d77\u558a，\u5c31\u80fd\u7a7f\u8fc7\u5608\u6742\u7684\u4f1a\u573a\u3002\u800c\u4e14\u6697\u53f7\u53ef\u4ee5\u968f\u65f6\u6539\u2014\u2014\u8fd9\u5c31\u662f IDR \u7684\u53ef\u8c03\u63a7\u6027\u3002<\/li>\n<\/ul>\n

          \u4e94\u3001\u8c03\u63a7：PTM\u3001\u73af\u5883\u4e0e\u201c\u4e0a\u4e0b\u6587\u201d<\/span><\/span><\/h3>\n
            \n
          • \u78f7\u9178\u5316\u3001\u4e59\u9170\u5316\u3001\u7532\u57fa\u5316\u7b49\u4fee\u9970\u53ef\u4ee5\u76f4\u63a5\u6539\u53d8 IDR \u7684\u7535\u8377\u4e0e\u6784\u8c61\u504f\u597d，\u4ece\u800c\u201c\u4e00\u952e\u5207\u6362\u201d\u7ed3\u5408\u5bf9\u8c61\u3002<\/li>\n
          • \u73af\u5883\u56e0\u7d20\u540c\u6837\u91cd\u8981：pH\u3001\u79bb\u5b50\u5f3a\u5ea6\u3001\u5206\u5b50\u62e5\u6324\u3001\u4ee5\u53ca\u76f8\u5206\u79bb\u503e\u5411，\u90fd\u4f1a\u6539\u53d8\u96c6\u5408\u6027\u8d28\u3002<\/li>\n
          • \u8fd9\u4f7f\u5f97 IDR \u6210\u4e3a\u201c\u73af\u5883\u4f20\u611f\u5668\u201d：\u540c\u4e00\u4e2a\u86cb\u767d，\u5728\u5e94\u6fc0\u6761\u4ef6\u4e0b\u53ef\u80fd\u83b7\u5f97\u5168\u65b0\u7684\u76f8\u4e92\u4f5c\u7528\u7f51\u7edc\u3002<\/li>\n
          • \u5927\u767d\u8bdd：\u6298\u53e0\u86cb\u767d\u7684\u72b6\u6001\u7531\u201c\u7ed3\u6784\u201d\u51b3\u5b9a，IDR \u7684\u72b6\u6001\u7531\u201c\u73af\u5883 + \u4fee\u9970\u201d\u5171\u540c\u51b3\u5b9a\u2014\u2014\u5b83\u66f4\u50cf\u4e00\u4e2a\u968f\u5929\u6c14\u6539\u53d8\u989c\u8272\u7684\u6307\u793a\u706f，\u800c\u4e0d\u662f\u4e00\u4e2a\u56fa\u5b9a\u7684\u5f00\u5173\u3002<\/li>\n<\/ul>\n

            \u516d\u3001\u75be\u75c5\u4e0e\u8bbe\u8ba1：\u4ece\u7a81\u53d8\u5230\u836f\u7269<\/span><\/span><\/h3>\n
              \n
            • IDR \u4e2d\u7684\u7a81\u53d8\u53ef\u4ee5\u901a\u8fc7\u591a\u79cd\u65b9\u5f0f\u81f4\u75c5：\u7834\u574f SLiM\u3001\u6539\u53d8\u7535\u8377\u6392\u5e03\u3001\u4ea7\u751f\u65b0\u7684\u805a\u96c6\u503e\u5411\u3001\u6216\u5f71\u54cd\u76f8\u5206\u79bb\u884c\u4e3a\u3002<\/li>\n
            • \u8fd9\u7c7b\u7a81\u53d8\u5f80\u5f80\u201c\u6548\u5e94\u6e29\u548c\u4f46\u5e7f\u6cdb\u201d\u2014\u2014\u4e0d\u50cf\u9176\u6d3b\u6027\u4f4d\u70b9\u7a81\u53d8\u90a3\u6837\u4e00\u9524\u5b9a\u97f3，\u800c\u662f\u540c\u65f6\u6270\u52a8\u591a\u4e2a\u76f8\u4e92\u4f5c\u7528\u3002<\/li>\n
            • \u836f\u7269\u5f00\u53d1\u56e0\u6b64\u66f4\u96be：\u6ca1\u6709\u660e\u786e\u7684\u201c\u53e3\u888b\u201d\u53ef\u4ee5\u7ed3\u5408；\u4f46\u53cd\u8fc7\u6765，\u9776\u5411 IDR \u7684\u754c\u9762\u6216\u76f8\u5206\u79bb\u884c\u4e3a，\u4e5f\u63d0\u4f9b\u4e86\u65b0\u7684\u601d\u8def\u3002<\/li>\n
            • \u6587\u7ae0\u7684\u5224\u65ad\u662f：\u6211\u4eec\u5bf9\u201c\u5e8f\u5217\u2014\u96c6\u5408\u2014\u529f\u80fd\u969c\u788d\u201d\u7684\u7406\u89e3\u4ecd\u5904\u4e8e\u8d77\u6b65\u9636\u6bb5，\u9700\u8981\u66f4\u7ec6\u81f4\u7684\u751f\u7269\u5316\u5b66\u7814\u7a76\u3002<\/li>\n
            • \u5927\u767d\u8bdd：IDR \u76f8\u5173\u75be\u75c5\u4e0d\u50cf\u201c\u94a5\u5319\u65ad\u4e86\u201d，\u66f4\u50cf\u201c\u793e\u4ea4\u5708\u4e71\u4e86\u201d\u2014\u2014\u4e0d\u662f\u67d0\u4e00\u4e2a\u8fde\u63a5\u574f\u4e86，\u800c\u662f\u6574\u4e2a\u4eba\u9645\u7f51\u7edc\u90fd\u504f\u4e86\u3002\u4fee\u8d77\u6765\u81ea\u7136\u66f4\u96be\u3002<\/li>\n<\/ul>\n

              \u4e03\u3001\u4e00\u53e5\u8bdd\u603b\u7ed3<\/span><\/span><\/h3>\n

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              \u514d\u8d23\u58f0\u660e： \u672c\u6587\u4e3a\u6587\u732e\u89e3\u8bfb\u4e0e\u79d1\u666e，\u4e0d\u6784\u6210\u4efb\u4f55\u8bca\u7597\u5efa\u8bae\u3002<\/p>\n

              \u5728Info X Med\u5373\u53ef\u67e5\u770b\u539f\u6587\u732e<\/p>\n

              \u6807\u7b7e： `#\u5185\u5728\u65e0\u5e8f\u86cb\u767d` `#IDR` `#\u6784\u8c61\u96c6\u5408` `#SLiM` `#\u591a\u4ef7\u76f8\u4e92\u4f5c\u7528` `#\u76f8\u5206\u79bb` `#\u6587\u732e\u89e3\u8bfb`<\/p>\n

              \u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

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