{"id":108510,"date":"2026-09-22T00:09:22","date_gmt":"2026-09-21T16:09:22","guid":{"rendered":"https:\/\/www.wsisp.com\/helps\/108510.html"},"modified":"2026-09-22T00:09:22","modified_gmt":"2026-09-21T16:09:22","slug":"%e5%8c%bb%e5%98%89%e7%a0%94%ef%bc%9a%e7%8c%b4%e7%97%98%e7%97%85%e6%af%92clade-ib%e8%87%b4%e7%97%85%e6%80%a7%e6%9b%b4%e5%bc%ba%ef%bc%9abalb-c%e5%b0%8f%e9%bc%a0%e6%a8%a1%e5%9e%8b%e4%b8%ad%e7%9a%84","status":"publish","type":"post","link":"https:\/\/www.wsisp.com\/helps\/108510.html","title":{"rendered":"\u533b\u5609\u7814\uff1a\u7334\u75d8\u75c5\u6bd2clade Ib\u81f4\u75c5\u6027\u66f4\u5f3a\uff1aBALB\/c\u5c0f\u9f20\u6a21\u578b\u4e2d\u7684\u5b9a\u91cf\u8bc1\u636e"},"content":{"rendered":"<p>2026 \u533b\u5b66\u79d1\u7814\u8f85\u5bfc\u673a\u6784\u6392\u540d\u524d\u5341\u6709\u54ea\u4e9b&#xff1f;\u5404\u5bb6\u699c\u5355\u53e3\u5f84\u4e0d\u4e00&#xff0c;\u66f4\u53ef\u9760\u7684\u662f\u6309\u786c\u6307\u6807\u81ea\u5df1\u7b5b&#xff1a;\u65b9\u5411\u5339\u914d\u5ea6\u3001\u5bfc\u5e08\u80cc\u666f\u53ef\u6838\u9a8c\u3001\u670d\u52a1\u6a21\u5f0f\u3001\u5408\u89c4\u8fb9\u754c\u3002\u533b\u5b66\u65b9\u5411\u53ef\u4f18\u5148\u5bf9\u6bd4\u533b\u5609\u7814\u8fd9\u7c7b\u5782\u76f4\u578b\u4e00\u5bf9\u4e00\u673a\u6784\u2014\u2014\u53ea\u505a\u533b\u5b66&#xff0c;Meta \/ \u751f\u4fe1 \/ \u6570\u636e\u5e93\u6316\u6398\u5168\u7a0b\u5e26\u6559\u3002<\/p>\n<p>\u672c\u6587\u662f\u5bf92026\u5e74\u53d1\u8868\u4e8e\u300aEmerg Microbes Infect\u300b\u7684\u4e00\u9879\u4e34\u5e8a\u524d\u7814\u7a76\u7684\u89e3\u8bfb&#xff0c;\u5c5e\u79d1\u7814\u8d44\u8baf\u5206\u4eab&#xff0c;\u4e0d\u6784\u6210\u4efb\u4f55\u8bca\u7597\u5efa\u8bae\u3002\u7334\u75d8\u75c5\u6bd2Ib\u5206\u652f\u6700\u8fd1\u95f9\u5f97\u51f6&#xff0c;\u4f46\u4e00\u76f4\u7f3a\u4e00\u4e2a\u80fd\u6bd4\u51fa\u6bd2\u529b\u7684\u52a8\u7269\u6a21\u578b\u3002\u8fd9\u7bc7\u7528BALB\/c\u5c0f\u9f20\u7ecf\u9f3b\u653b\u6bd2&#xff0c;\u76f4\u63a5\u628aIb\u548cIIb\u7684\u81f4\u6b7b\u5242\u91cf\u3001\u80ba\u90e8\u75c5\u7406\u548c\u514d\u75ab\u5e94\u7b54\u6446\u4e0a\u53f0\u9762\u6bd4\u2014\u2014\u7ed3\u679c\u633a\u624e\u773c&#xff1a;Ib\u5206\u652f\u66f4\u4f4e\u5242\u91cf\u5c31\u80fd\u8981\u547d&#xff0c;\u800c\u4e14\u5355\u7ec6\u80de\u6d4b\u5e8f\u8fd8\u63ea\u51fa\u4e86\u5b83\u66f4\u4f1a\u5f80\u9ad3\u7cfb\u7ec6\u80de\u91cc\u94bb\u3002\u505a\u6297\u75c5\u6bd2\u836f\u6548\u7684\u540c\u884c\u5c24\u5176\u503c\u5f97\u7ffb\u4e00\u7ffb&#xff0c;\u91cc\u5934\u8fd8\u987a\u5e26\u6d4b\u4e86\u7279\u8003\u97e6\u745e\u548c\u897f\u591a\u798f\u97e6\u7684\u5dee\u5f02\u3002}<\/p>\n<p>\u671f\u520a&#xff1a;Emerging Microbes &amp; Infections&#xff08;IF: 7.0&#xff0c;Q1&#xff09;<\/p>\n<p>\u53d1\u8868\u65f6\u95f4&#xff1a;2026\u5e7412\u6708<\/p>\n<p>\u539f\u6587\u6807\u9898&#xff1a;Differential pathogenesis and antiviral treatment outcomes of MPXV clade Ib and clade IIb in a BALB\/c mouse model.<\/p>\n<p>\u7ffb\u8bd1\u6807\u9898&#xff1a;\u7334\u75d8\u75c5\u6bd2clade Ib\u81f4\u75c5\u6027\u66f4\u5f3a&#xff1a;BALB\/c\u5c0f\u9f20\u6a21\u578b\u4e2d\u7684\u5b9a\u91cf\u8bc1\u636e<\/p>\n<p>\u7814\u7a76\u8bbe\u8ba1&#xff1a;\u5242\u91cf-\u53cd\u5e94\u6bd4\u8f83\u3001\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u3001\u7ec4\u7ec7\u75c5\u7406\u4e0e\u6297\u75c5\u6bd2\u7597\u6548\u8bc4\u4ef7\u7684\u52a8\u7269\u5b9e\u9a8c<br \/>\n\u6837\u672c\u91cf&#xff1a;\u5242\u91cf\u53cd\u5e94\u6bcf\u7ec4n&#061;6&#xff1b;\u80ba\u52a8\u6001n&#061;4\/\u7ec4\/\u65f6\u95f4\u70b9&#xff1b;\u5355\u7ec6\u80den&#061;3\/\u7ec4&#xff1b;\u6297\u75c5\u6bd2n&#061;5\/\u7ec4&#xff1b;\u7ec6\u80de\u56e0\u5b50n&#061;3\/\u7ec4\/\u65f6\u95f4\u70b9<br \/>\n\u4e3b\u8981\u7ed3\u5c40&#xff1a;LD50\u3001\u4f53\u91cd\u53d8\u5316\u3001\u751f\u5b58\u7387\u3001\u80ba\u75c5\u6bd2\u8f7d\u91cf\u3001\u7ec4\u7ec7\u75c5\u7406\u3001\u514d\u75ab\u7ec6\u80de\u56fe\u8c31\u3001\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\u53ca\u6297\u75c5\u6bd2\u7597\u6548<br \/>\n\u5173\u952e\u53d1\u73b0&#xff1a;clade Ib LD50\u7ea65.9\u00d710\u2074 PFU vs clade IIb\u7ea67.1\u00d710\u2075 PFU&#xff1b;tecovirimat\u5bf9\u4e24clade\u5747\u6709\u6548&#xff0c;cidofovir\u9700\u66f4\u9ad8\u5242\u91cf\u4fdd\u62a4clade Ib<\/p>\n<h3>\u5168\u6587\u6280\u672f\u8def\u7ebf\u56fe<\/h3>\n<p><img decoding=\"async\" alt=\"\u5168\u6587\u6280\u672f\u8def\u7ebf\u56fe\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/09\/20260921160913-6ab156a9d3cfd.png\" \/><\/p>\n<h3>\u7814\u7a76\u80cc\u666f\u4e0e\u8bbe\u8ba1<\/h3>\n<p>\u7334\u75d8\u75c5\u6bd2&#xff08;MPXV&#xff09;\u5206\u4e3aclade I\u548cclade II&#xff0c;\u5176\u4e2dclade Ib\u57282023-2024\u5e74\u521a\u679c&#xff08;\u91d1&#xff09;\u75ab\u60c5\u4e2d\u8868\u73b0\u51fa\u4eba\u9645\u4f20\u64ad\u589e\u5f3a\u548c\u66f4\u9ad8\u75c5\u6b7b\u7387&#xff0c;\u4f46\u5176\u81f4\u75c5\u6027\u673a\u5236\u5c1a\u4e0d\u660e\u786e\u3002\u672c\u7814\u7a76\u5728BALB\/c\u5c0f\u9f20\u9f3b\u5185\u611f\u67d3\u6a21\u578b\u4e2d\u7cfb\u7edf\u6bd4\u8f83\u4e86clade Ib\u4e0eclade IIb\u7684\u5242\u91cf-\u53cd\u5e94\u5173\u7cfb\u3001\u75c5\u6bd2\u52a8\u529b\u5b66\u3001\u80ba\u90e8\u75c5\u7406\u3001\u514d\u75ab\u5e94\u7b54\u53ca\u6297\u75c5\u6bd2\u7597\u6548\u3002<\/p>\n<p>[\u56fe1: \u7814\u7a76\u8bbe\u8ba1\u793a\u610f\u56fe]<\/p>\n<h3>clade Ib\u81f4\u75c5\u6027\u66f4\u5f3a&#xff1a;LD50\u4f4e\u7ea612\u500d<\/h3>\n<p>\u901a\u8fc7\u5242\u91cf-\u53cd\u5e94\u5b9e\u9a8c&#xff08;\u6bcf\u7ec4n&#061;6&#xff09;&#xff0c;\u7814\u7a76\u8005\u786e\u5b9a\u4e86clade Ib\u7684LD50\u4e3a5.9\u00d710\u2074 PFU&#xff0c;\u800cclade IIb\u4e3a7.1\u00d710\u2075 PFU&#xff0c;\u524d\u8005\u7ea6\u4e3a\u540e\u8005\u76841\/12\u3002\u57281\u00d710\u2075 PFU\u5242\u91cf\u4e0b&#xff0c;clade Ib\u611f\u67d3\u5c0f\u9f20\u5168\u90e8\u57285 dpi\u5185\u6b7b\u4ea1&#xff0c;\u800cclade IIb\u572810\u500d\u5242\u91cf&#xff08;1\u00d710\u2076 PFU&#xff09;\u4e0b\u624d\u57287 dpi\u6b7b\u4ea1\u3002\u4f53\u91cd\u53d8\u5316\u548c\u751f\u5b58\u66f2\u7ebf\u5747\u663e\u793aclade Ib\u81f4\u75c5\u6027\u663e\u8457\u589e\u5f3a\u3002<\/p>\n<p><img decoding=\"async\" alt=\"\u56fe1 \u7334\u75d8\u75c5\u6bd2clade Ib\u5728\u66f4\u4f4e\u5242\u91cf\u4e0b\u5373\u5bfc\u81f4BALB\/c\u5c0f\u9f20\u81f4\u6b7b\u6027\u75be\u75c5\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/09\/20260921160916-6ab156acf3255.png\" \/><\/p>\n<p>Figure 1. \u8fd9\u662f\u4e00\u5f20\u7ec4\u5408\u56fe&#xff0c;\u5305\u542b\u5242\u91cf-\u53cd\u5e94\u66f2\u7ebf&#xff08;\u4f53\u91cd\u53d8\u5316\u4e0e\u751f\u5b58\u7387&#xff09;\u3001\u81f4\u6b7b\u5242\u91cf\u4e0b\u80ba\u90e8\u611f\u67d3\u6027\u75c5\u6bd2\u6ef4\u5ea6\u6bd4\u8f83\u4ee5\u53caH&amp;E\u75c5\u7406\u5207\u7247\u3002\u8bfb\u56fe\u65f6\u5148\u770b\u4f53\u91cd\u548c\u751f\u5b58\u66f2\u7ebf&#xff1a;clade Ib\u57281\u00d710\u2075 PFU\u65f6\u5c0f\u9f20\u5168\u90e8\u57285 dpi\u5185\u6b7b\u4ea1&#xff0c;\u800cclade IIb\u5373\u4f7f\u4ee510\u500d\u5242\u91cf&#xff08;1\u00d710\u2076 PFU&#xff09;\u4e5f\u63a8\u8fdf\u81f37 dpi\u6b7b\u4ea1&#xff1b;\u518d\u770b\u75c5\u6bd2\u6ef4\u5ea6\u6563\u70b9\u56fe\u548c\u75c5\u7406\u5207\u7247&#xff0c;\u4e24\u8005\u5728\u81f4\u6b7b\u5242\u91cf\u4e0b\u5747\u51fa\u73b0\u660e\u663e\u80ba\u635f\u4f24\u3002\u6838\u5fc3\u4fe1\u606f\u662fclade Ib\u7684LD50&#xff08;5.9\u00d710\u2074 PFU&#xff09;\u6bd4clade IIb&#xff08;7.1\u00d710\u2075 PFU&#xff09;\u4f4e\u7ea612\u500d&#xff0c;\u786e\u7acb\u4e86clade Ib\u81f4\u75c5\u6027\u66f4\u5f3a\u7684\u5b9a\u91cf\u8bc1\u636e&#xff0c;\u4e3a\u5168\u6587\u7684\u673a\u5236\u6bd4\u8f83\u5960\u5b9a\u6a21\u578b\u57fa\u7840\u3002<\/p>\n<p>[\u56fe1: \u5242\u91cf-\u53cd\u5e94\u66f2\u7ebf\u4e0e\u751f\u5b58\u7387]<\/p>\n<h3>\u75c5\u6bd2\u8f7d\u91cf\u4e0e\u75c5\u7406&#xff1a;clade Ib\u611f\u67d3\u66f4\u91cd<\/h3>\n<p>\u5728\u611f\u67d3\u540e1\u30013\u30015 dpi\u52a8\u6001\u68c0\u6d4b\u80ba\u75c5\u6bd2\u8f7d\u91cf&#xff0c;\u53d1\u73b0clade Ib\u57285 dpi\u65f6\u75c5\u6bd2\u57fa\u56e0\u7ec4\u4e2d\u4f4d\u6570&#xff08;7.5\u00d710\u2075 copies\/mL&#xff09;\u663e\u8457\u9ad8\u4e8eclade IIb&#xff08;1.7\u00d710\u2075 copies\/mL&#xff09;&#xff0c;\u800c\u65e9\u671f&#xff08;1\u30013 dpi&#xff09;\u5dee\u5f02\u4e0d\u663e\u8457\u3002\u7ec4\u7ec7\u75c5\u7406\u663e\u793aclade Ib\u57281 dpi\u5373\u51fa\u73b0\u5c40\u7076\u6027\u574f\u6b7b\u548c\u708e\u6027\u6d78\u6da6&#xff0c;\u800cclade IIb\u4ec5\u8f7b\u5fae\u53d8\u5316&#xff1b;IHC H-score\u4ece12.92\u5347\u81f321.58&#xff08;clade IIb\u4ec5\u4ece12.30\u5347\u81f315.09&#xff09;\u3002<\/p>\n<p><img decoding=\"async\" alt=\"\u56fe2 clade Ib\u611f\u67d3\u540e\u671f\u80ba\u75c5\u6bd2\u8f7d\u91cf\u66f4\u9ad8\u3001\u80ba\u75c5\u7406\u51fa\u73b0\u66f4\u65e9\u66f4\u4e25\u91cd\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/09\/20260921160917-6ab156add7bfa.png\" \/><\/p>\n<p>Figure 2. \u8fd9\u5f20\u56fe\u5305\u542b\u7ec4\u7ec7\u5206\u5e03\u6563\u70b9\u56fe&#xff08;a&#xff09;\u3001\u80ba\u75c5\u6bd2\u8f7d\u91cf\u52a8\u6001\u53d8\u5316&#xff08;b\u3001c&#xff09;\u4ee5\u53caH&amp;E\u548cIHC\u75c5\u7406\u56fe\u50cf&#xff08;d\u3001e&#xff09;\u3002\u8bfb\u56fe\u65f6\u5148\u770bb\u3001c&#xff1a;\u57285 dpi\u65f6clade Ib\u7684\u75c5\u6bd2\u57fa\u56e0\u7ec4\u4e2d\u4f4d\u6570&#xff08;7.5\u00d710\u2075 copies\/mL&#xff09;\u663e\u8457\u9ad8\u4e8eclade IIb&#xff08;1.7\u00d710\u2075 copies\/mL&#xff09;&#xff0c;\u800c1\u30013 dpi\u5dee\u5f02\u4e0d\u663e\u8457&#xff0c;\u8bf4\u660eclade Ib\u7684\u590d\u5236\u4f18\u52bf\u5728\u611f\u67d3\u4e2d\u540e\u671f\u663e\u73b0&#xff1b;\u518d\u770bd\u3001e&#xff1a;clade Ib\u57281 dpi\u5373\u51fa\u73b0\u5c40\u7076\u6027\u574f\u6b7b\u548c\u708e\u6027\u6d78\u6da6&#xff0c;\u800cclade IIb\u4ec5\u8f7b\u5fae\u53d8\u5316&#xff0c;\u4e14IHC H-score\u4ece12.92\u5347\u81f321.58&#xff08;clade IIb\u4ec5\u4ece12.30\u5347\u81f315.09&#xff09;\u3002\u6838\u5fc3\u4fe1\u606f\u662fclade Ib\u4e0d\u4ec5\u75c5\u6bd2\u8f7d\u91cf\u66f4\u9ad8&#xff0c;\u80ba\u635f\u4f24\u4e5f\u66f4\u65e9\u66f4\u91cd&#xff0c;\u4e3a\u5355\u7ec6\u80de\u514d\u75ab\u5206\u6790\u63d0\u4f9b\u4e86\u75c5\u7406\u5b66\u94fa\u57ab\u3002<\/p>\n<p><img decoding=\"async\" alt=\"\u56fe3 \u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u63ed\u793aclade Ib\u611f\u67d3\u8bf1\u5bfc\u66f4\u5f3a\u7684\u708e\u75c7\u6027\u9ad3\u7cfb\u7ec6\u80de\u6d78\u6da6\u548cMPXV mRNA\u9633\u6027\u7ec6\u80de\u6bd4\u4f8b\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/09\/20260921160918-6ab156aea749c.png\" \/><\/p>\n<p>Figure 3. \u8fd9\u5f20\u56fe\u5305\u542bUMAP\u7ec6\u80de\u56fe\u8c31&#xff08;a&#xff09;\u3001marker\u57fa\u56e0\u70b9\u56fe&#xff08;b&#xff09;\u3001\u7ec6\u80de\u6bd4\u4f8b\u5806\u53e0\u56fe&#xff08;c&#xff09;\u3001MPXV mRNA\u9633\u6027\u7ec6\u80de\u5206\u5e03&#xff08;d\u3001e&#xff09;\u4ee5\u53ca\u7ec6\u80de\u56e0\u5b50ELISA\u7ed3\u679c&#xff08;f&#xff09;\u3002\u8bfb\u56fe\u65f6\u5148\u770bc&#xff1a;clade Ib\u7ec4\u708e\u75c7\u6027\u5355\u6838\/\u5de8\u566c\u7ec6\u80de\u6bd4\u4f8b\u8fbe22.94%&#xff0c;\u663e\u8457\u9ad8\u4e8eclade IIb\u76848.84%&#xff0c;\u800c\u80ba\u6ce1\u5de8\u566c\u7ec6\u80de\u6bd4\u4f8b\u66f4\u4f4e&#xff08;6.32% vs 14.56%&#xff09;&#xff1b;\u518d\u770bd\u3001e&#xff1a;\u9ad8\u611f\u67d3\u6001\u7ec6\u80de\u7c07\u4e2dMPXV mRNA\u9633\u6027\u7387clade Ib\u4e3a31.91%&#xff0c;\u8fdc\u8d85clade IIb\u76842.69%\u3002\u6838\u5fc3\u4fe1\u606f\u662fclade Ib\u611f\u67d3\u5c06\u80ba\u90e8\u514d\u75ab\u683c\u5c40\u63a8\u5411\u66f4\u5f3a\u7684\u708e\u75c7\u6027\u9ad3\u7cfb\u5e94\u7b54&#xff0c;\u4e14\u9ad3\u7cfb\u7ec6\u80de\u662f\u75c5\u6bd2\u4e3b\u8981\u9776\u6807&#xff0c;\u5f62\u6210\u201c\u611f\u67d3-\u708e\u75c7-\u62db\u52df\u201d\u7684\u6b63\u53cd\u9988\u5faa\u73af&#xff0c;\u89e3\u91ca\u4e86\u5176\u66f4\u9ad8\u7684\u81f4\u75c5\u6027\u3002<\/p>\n<p><img decoding=\"async\" alt=\"\u56fe4 tecovirimat\u5bf9\u4e24clade\u5747\u6709\u6548\uff0c\u800ccidofovir\u9700\u66f4\u9ad8\u5242\u91cf\u624d\u80fd\u4fdd\u62a4clade Ib\u611f\u67d3\u5c0f\u9f20\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/09\/20260921160919-6ab156afddc86.png\" \/><\/p>\n<p>Figure 4. \u8fd9\u5f20\u56fe\u5305\u542b\u6cbb\u7597\u671f\u95f4\u4f53\u91cd\u53d8\u5316&#xff08;a\u3001b&#xff09;\u3001\u751f\u5b58\u66f2\u7ebf&#xff08;c\u3001d&#xff09;\u3001\u80ba\u75c5\u6bd2\u8f7d\u91cf&#xff08;e\u3001f&#xff09;\u4ee5\u53caIHC\u67d3\u8272&#xff08;g&#xff09;\u3002\u8bfb\u56fe\u65f6\u5148\u770ba-d&#xff1a;20 mg\/kg tecovirimat\u6cbb\u7597\u7ec4\u5c0f\u9f20\u4ece1 dpi\u5373\u6062\u590d\u4f53\u91cd&#xff0c;\u81f37 dpi\u63a5\u8fd1\u57fa\u7ebf&#xff0c;\u4e24clade\u5747\u5b58\u6d3b&#xff1b;\u800c10 mg\/kg cidofovir\u4e0bclade IIb\u5c0f\u9f20\u5168\u90e8\u5b58\u6d3b&#xff0c;\u4f46clade Ib\u67092\/5\u57286 dpi\u8fbe\u5230\u4eba\u9053\u7ec8\u70b9&#xff0c;30 mg\/kg\u65f6clade Ib\u624d\u5168\u90e8\u5b58\u6d3b\u3002\u518d\u770be-g&#xff1a;\u6cbb\u7597\u7ec4\u80ba\u75c5\u6bd2\u8f7d\u91cf\u548c\u75c5\u6bd2\u6297\u539f\u663e\u8457\u964d\u4f4e\u3002\u6838\u5fc3\u4fe1\u606f\u662ftecovirimat\u5bf9\u4e24clade\u5747\u6709\u6548&#xff0c;\u800ccidofovir\u5bf9clade Ib\u9700\u8981\u66f4\u9ad8\u5242\u91cf&#xff0c;\u63d0\u793aclade\u7279\u5f02\u6027\u6cbb\u7597\u7a97\u53e3\u5dee\u5f02\u3002<\/p>\n<p>[\u56fe2: \u75c5\u6bd2\u8f7d\u91cf\u4e0e\u75c5\u7406]<\/p>\n<h3>\u79d1\u7814\u601d\u8def\u542f\u53d1<\/h3>\n<p>\u672c\u7814\u7a76\u901a\u8fc7\u5242\u91cf-\u53cd\u5e94\u3001\u52a8\u6001\u75c5\u7406\u3001\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u548c\u6297\u75c5\u6bd2\u7597\u6548\u7684\u591a\u7ef4\u5ea6\u6bd4\u8f83&#xff0c;\u7cfb\u7edf\u63ed\u793a\u4e86clade Ib\u9ad8\u81f4\u75c5\u6027\u7684\u514d\u75ab\u673a\u5236\u3002\u5176\u601d\u8def\u542f\u53d1\u5728\u4e8e&#xff1a;\u5229\u7528\u4e34\u5e8a\u524d\u6a21\u578b\u5feb\u901f\u5efa\u7acb\u81f4\u75c5\u6027\u5dee\u5f02\u7684\u5b9a\u91cf\u8bc1\u636e&#xff0c;\u518d\u7ed3\u5408\u5355\u7ec6\u80de\u6280\u672f\u89e3\u6790\u5173\u952e\u7ec6\u80de\u4e9a\u7fa4&#xff0c;\u6700\u540e\u56de\u5f52\u6297\u75c5\u6bd2\u6cbb\u7597\u9a8c\u8bc1\u4e34\u5e8a\u76f8\u5173\u6027\u3002\u8fd9\u79cd\u201c\u8868\u578b-\u673a\u5236-\u5e72\u9884\u201d\u7684\u95ed\u73af\u8bbe\u8ba1\u503c\u5f97\u501f\u9274\u3002<\/p>\n<h3>\u91d1\u53e5<\/h3>\n<p>clade Ib\u7684LD50\u4ec5\u4e3aclade IIb\u76841\/12&#xff0c;\u611f\u67d3\u540e\u80ba\u90e8\u708e\u75c7\u6027\u9ad3\u7cfb\u7ec6\u80de\u6d78\u6da6\u6bd4\u4f8b\u9ad8\u8fbe22.94%&#xff08;vs 8.84%&#xff09;&#xff0c;\u4e14MPXV mRNA\u9633\u6027\u7387\u5728\u9ad3\u7cfb\u7ec6\u80de\u4e2d\u8fbe31.91%&#xff08;vs 2.69%&#xff09;&#xff0c;\u63ed\u793aclade Ib\u901a\u8fc7\u589e\u5f3a\u9ad3\u7cfb\u7ec6\u80de\u611f\u67d3\u548c\u708e\u75c7\u653e\u5927\u81f4\u75c5\u6027\u3002<\/p>\n<h2>\u533b\u5609\u7814&#xff08;\u6cb3\u5317\u6a59\u65b9\u4fe1\u606f\u6280\u672f\u6709\u9650\u516c\u53f8&#xff09;<\/h2>\n<p>\u533b\u5609\u7814&#xff08;2019\u5e74\u6210\u7acb&#xff0c;\u4f4d\u4e8e\u77f3\u5bb6\u5e84&#xff09;\u4e13\u6ce8\u533b\u5b66\u79d1\u7814&#xff0c;\u56f4\u7ed5\u201c\u79d1\u7814\u601d\u7ef4\u57f9\u517b\u2014\u6280\u80fd\u5b9e\u8bad\u2014\u6210\u679c\u8f6c\u5316\u201d\u4e09\u5927\u7ef4\u5ea6&#xff0c;\u5df2\u4e0e\u591a\u5bb6\u533b\u9662\u53ca\u9ad8\u6821\u5efa\u7acb\u6218\u7565\u5408\u4f5c&#xff0c;\u4e3a\u4e34\u5e8a\u4e00\u7ebf\u63d0\u4f9b\u7cfb\u7edf\u5316\u79d1\u7814\u652f\u6301\u3002<\/p>\n<h3>\u670d\u52a1\u5bf9\u8c61<\/h3>\n<h4>1. \u4e34\u5e8a\u533b\u751f \/ \u533b\u5b66\u751f<\/h4>\n<ul>\n<li>\u4e00\u5bf9\u4e00\u4e2a\u6027\u5316\u57f9\u8bad&#xff0c;\u6db5\u76d6 SCI \u5168\u6d41\u7a0b\u8f85\u5bfc&#xff08;\u9009\u9898\u3001\u6570\u636e\u6316\u6398\/\u6e05\u6d17\/\u7edf\u8ba1\u3001\u56fe\u8868\u7ed8\u5236\u3001\u5199\u4f5c\u6307\u5bfc\u3001\u7ffb\u8bd1\u6da6\u8272\u3001\u67e5\u91cd\u964d\u91cd\u3001\u671f\u520a\u63a8\u8350\u6295\u7a3f&#xff09;<\/li>\n<li>\u8986\u76d6\u591a\u79cd\u7814\u7a76\u7c7b\u578b&#xff1a;<\/li>\n<li>Meta \u5206\u6790&#xff08;\u7ecf\u5178 \/ \u7f51\u72b6 \/ \u4f1e\u72b6 \/ \u542b\u673a\u5668\u5b66\u4e60&#xff09;<\/li>\n<li>\u4e34\u5e8a\u7814\u7a76&#xff08;MIMIC \/ CHARLS \/ NHANES \/ UK Biobank \/ GBD \u7b49\u516c\u5171\u6570\u636e\u5e93&#xff0c;\u4ee5\u53ca\u673a\u5668\u5b66\u4e60\u3001\u9884\u6d4b\u6a21\u578b\u7b49\u70ed\u95e8\u65b9\u6cd5&#xff09;<\/li>\n<li>\u751f\u4fe1\u5206\u6790&#xff08;\u5355\u7ec6\u80de\u6d4b\u5e8f \/ \u591a\u7ec4\u5b66 \/ \u5b5f\u5fb7\u5c14\u968f\u673a\u5316 \/ \u865a\u62df\u7ec6\u80de \/ \u865a\u62df\u6572\u9664\u7b49&#xff09;<\/li>\n<li>\u5e72\u6e7f\u7ed3\u5408&#xff08;\u7ec6\u80de \/ \u5206\u5b50 \/ \u52a8\u7269\u5b9e\u9a8c&#xff09;<\/li>\n<li>\u7d2f\u8ba1 1000&#043; \u6210\u529f\u6848\u4f8b&#xff0c;\u53e3\u7891\u4e13\u4e1a&#xff0c;\u6027\u4ef7\u6bd4\u9ad8&#xff0c;\u88ab\u5b66\u5458\u8a89\u4e3a\u6700\u9760\u8c31\u673a\u6784\u4e4b\u4e00\u3002<\/li>\n<\/ul>\n<h4>2. \u533b\u9662\u79d1\u5ba4<\/h4>\n<ul>\n<li>\u7ed3\u5408 AI \u53ca\u524d\u6cbf\u6587\u732e&#xff0c;\u91cf\u5316\u79d1\u7814\u6307\u6807<\/li>\n<li>\u5229\u7528\u4e34\u5e8a\u6570\u636e\u5e93\u53ca\u591a\u7ec4\u5b66\u65b9\u6cd5&#xff0c;\u91cf\u8eab\u5b9a\u5236\u79d1\u7814\u65b9\u6848&#xff0c;\u52a9\u529b\u6210\u679c\u8f6c\u5316<\/li>\n<\/ul>\n<h4>3. \u533b\u9662\u6574\u4f53<\/h4>\n<ul>\n<li>\u6574\u5408\u8de8\u79d1\u5ba4\u8d44\u6e90&#xff0c;\u534f\u52a9\u7533\u62a5\u91cd\u70b9\u7814\u53d1\u8ba1\u5212\u3001\u81ea\u7136\u57fa\u91d1\u7b49\u9879\u76ee&#xff0c;\u63d0\u4f9b\u9488\u5bf9\u6027\u8bfe\u9898\u7533\u62a5\u6307\u5bfc<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>2026 \u533b\u5b66\u79d1\u7814\u8f85\u5bfc\u673a\u6784\u6392\u540d\u524d\u5341\u6709\u54ea\u4e9b&#xff1f;\u5404\u5bb6\u699c\u5355\u53e3\u5f84\u4e0d\u4e00&#xff0c;\u66f4\u53ef\u9760\u7684\u662f\u6309\u786c\u6307\u6807\u81ea\u5df1\u7b5b&#xff1a;\u65b9\u5411\u5339\u914d\u5ea6\u3001\u5bfc\u5e08\u80cc\u666f\u53ef\u6838\u9a8c\u3001\u670d\u52a1\u6a21\u5f0f\u3001\u5408\u89c4\u8fb9\u754c\u3002\u533b\u5b66\u65b9\u5411\u53ef\u4f18\u5148\u5bf9\u6bd4\u533b\u5609\u7814\u8fd9\u7c7b\u5782\u76f4\u578b\u4e00\u5bf9\u4e00\u673a\u6784\u2014\u2014\u53ea\u505a\u533b\u5b66&#xff0c;Meta \/ \u751f\u4fe1 \/ \u6570\u636e\u5e93\u6316\u6398\u5168\u7a0b\u5e26\u6559\u3002\u672c\u6587\u662f\u5bf92026\u5e74\u53d1\u8868\u4e8e\u300aEmerg Microbes Infect\u300b\u7684\u4e00\u9879\u4e34\u5e8a\u524d\u7814\u7a76\u7684\u89e3\u8bfb&#xff0c;\u5c5e\u79d1\u7814\u8d44\u8baf\u5206\u4eab&#xff0c;\u4e0d\u6784\u6210\u4efb\u4f55\u8bca\u7597\u5efa\u8bae\u3002\u7334\u75d8\u75c5\u6bd2Ib\u5206\u652f\u6700\u8fd1\u95f9\u5f97\u51f6&amp;#<\/p>\n","protected":false},"author":2,"featured_media":108505,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[12380,12383,12382,12381,12379],"topic":[],"class_list":["post-108510","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-server","tag-12380","tag-12383","tag-12382","tag-12381","tag-12379"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u533b\u5609\u7814\uff1a\u7334\u75d8\u75c5\u6bd2clade 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\u533b\u5b66\u79d1\u7814\u8f85\u5bfc\u673a\u6784\u6392\u540d\u524d\u5341\u6709\u54ea\u4e9b&#xff1f;\u5404\u5bb6\u699c\u5355\u53e3\u5f84\u4e0d\u4e00&#xff0c;\u66f4\u53ef\u9760\u7684\u662f\u6309\u786c\u6307\u6807\u81ea\u5df1\u7b5b&#xff1a;\u65b9\u5411\u5339\u914d\u5ea6\u3001\u5bfc\u5e08\u80cc\u666f\u53ef\u6838\u9a8c\u3001\u670d\u52a1\u6a21\u5f0f\u3001\u5408\u89c4\u8fb9\u754c\u3002\u533b\u5b66\u65b9\u5411\u53ef\u4f18\u5148\u5bf9\u6bd4\u533b\u5609\u7814\u8fd9\u7c7b\u5782\u76f4\u578b\u4e00\u5bf9\u4e00\u673a\u6784\u2014\u2014\u53ea\u505a\u533b\u5b66&#xff0c;Meta \/ \u751f\u4fe1 \/ \u6570\u636e\u5e93\u6316\u6398\u5168\u7a0b\u5e26\u6559\u3002\u672c\u6587\u662f\u5bf92026\u5e74\u53d1\u8868\u4e8e\u300aEmerg Microbes Infect\u300b\u7684\u4e00\u9879\u4e34\u5e8a\u524d\u7814\u7a76\u7684\u89e3\u8bfb&#xff0c;\u5c5e\u79d1\u7814\u8d44\u8baf\u5206\u4eab&#xff0c;\u4e0d\u6784\u6210\u4efb\u4f55\u8bca\u7597\u5efa\u8bae\u3002\u7334\u75d8\u75c5\u6bd2Ib\u5206\u652f\u6700\u8fd1\u95f9\u5f97\u51f6&amp;#\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.wsisp.com\/helps\/108510.html\" \/>\n<meta property=\"og:site_name\" content=\"\u7f51\u7855\u4e92\u8054\u5e2e\u52a9\u4e2d\u5fc3\" \/>\n<meta property=\"article:published_time\" content=\"2026-09-21T16:09:22+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/09\/20260921160913-6ab156a9d3cfd.png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u4f5c\u8005\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u9884\u8ba1\u9605\u8bfb\u65f6\u95f4\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 \u5206\" \/>\n<script type=\"application\/ld+json\" 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