{"id":102831,"date":"2026-09-09T14:49:19","date_gmt":"2026-09-09T06:49:19","guid":{"rendered":"https:\/\/www.wsisp.com\/helps\/102831.html"},"modified":"2026-09-09T14:49:19","modified_gmt":"2026-09-09T06:49:19","slug":"%e4%b8%80%e6%96%87%e8%af%bb%e6%87%82-alphafold%ef%bc%9a%e8%af%ba%e5%a5%96nature%e5%8f%8c%e5%8a%a0%e5%86%95%ef%bc%8c%e7%a9%b6%e7%ab%9f%e7%89%9b%e5%9c%a8%e5%93%aa%e9%87%8c%ef%bc%9f%e5%8e%9f%e7%90%86","status":"publish","type":"post","link":"https:\/\/www.wsisp.com\/helps\/102831.html","title":{"rendered":"\u4e00\u6587\u8bfb\u61c2 AlphaFold\uff1a\u8bfa\u5956+Nature\u53cc\u52a0\u5195\uff0c\u7a76\u7adf\u725b\u5728\u54ea\u91cc\uff1f\u539f\u7406\/\u53d1\u5c55\/\u7ed3\u679c\u89e3\u8bfb\/\u5e94\u7528\u6587\u732e\u6848\u4f8b"},"content":{"rendered":"<p>\u86cb\u767d\u8d28\u529f\u80fd\u9ad8\u5ea6\u4f9d\u8d56\u4e09\u7ef4\u7a7a\u95f4\u6784\u8c61&#xff0c;\u957f\u671f\u4ee5\u6765\u53d7\u9650\u4e8e\u5b9e\u9a8c\u6210\u672c\u9ad8\u3001\u901a\u91cf\u4f4e\u7b49\u74f6\u9888&#xff0c;\u4e3a\u7a81\u7834\u8fd9\u4e00\u96be\u9898&#xff0c;\u8c37\u6b4cDeepMind\u56e2\u961f\u7814\u53d1\u51faAlphaFold\u4eba\u5de5\u667a\u80fd\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u7cfb\u7edf&#xff0c;\u5f7b\u5e95\u9769\u65b0\u4e86\u4f20\u7edf\u86cb\u767d\u8d28\u89e3\u6790\u7684\u6280\u672f\u8def\u5f84&#xff0c;\u6210\u4e3a\u7ed3\u6784\u751f\u7269\u5b66\u4e0e\u836f\u7269\u7814\u53d1\u9886\u57df\u7684\u98a0\u8986\u6027\u6280\u672f\u3002\u4e0d\u540c\u4e8e\u51b7\u51bb\u7535\u955c\u3001X\u5c04\u7ebf\u884d\u5c04\u7b49\u4f20\u7edf\u4f9d\u8d56\u590d\u6742\u5b9e\u9a8c\u8bbe\u5907\u3001\u4eba\u5de5\u64cd\u4f5c\u7684\u89e3\u6790\u624b\u6bb5&#xff0c;AlphaFold\u4f9d\u6258\u6df1\u5ea6\u5b66\u4e60\u7b97\u6cd5&#xff0c;\u4ec5\u901a\u8fc7\u86cb\u767d\u8d28\u4e00\u7ef4\u6c28\u57fa\u9178\u5e8f\u5217&#xff0c;\u5373\u53ef\u5feb\u901f\u9884\u6d4b\u5176\u4e09\u7ef4\u7a7a\u95f4\u7ed3\u6784&#xff0c;\u5b8c\u7f8e\u7834\u89e3\u4e86\u4f20\u7edf\u5b9e\u9a8c\u89e3\u6790\u7684\u8bf8\u591a\u75db\u70b9&#xff0c;\u5927\u5e45\u964d\u4f4e\u79d1\u7814\u95e8\u69db\u3001\u63d0\u5347\u7814\u7a76\u6548\u7387\u3002<\/p>\n<\/p>\n<p class=\"img-center\"><img loading=\"lazy\" decoding=\"async\" alt=\"\u56fe\u7247\" height=\"864\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/09\/20260909064914-6aa1016a9cf73.png\" width=\"692\" \/><\/p>\n<\/p>\n<p>2020\u5e74DeepMind\u63a8\u51fa\u7684AlphaFold2\u6a21\u578b\u53ef\u6839\u636e\u86cb\u767d\u7684\u6c28\u57fa\u9178\u5e8f\u5217&#xff0c;\u9884\u6d4b\u63a5\u8fd1\u771f\u5b9e\u72b6\u6001\u7684\u86cb\u767d\u8d28\u4e09\u7ef4\u7ed3\u6784\u30022024\u5e74\u6b63\u5f0f\u63a8\u51faAlphaFold3\u6a21\u578b&#xff0c;\u5e76\u767b\u9876\u300aNature\u300b&#xff0c;\u8fdb\u4e00\u6b65\u7a81\u7834\u5355\u4e00\u86cb\u767d\u9884\u6d4b\u8fb9\u754c&#xff0c;\u5b9e\u73b0\u4e86\u86cb\u767d\u8d28\u3001DNA\u3001RNA\u53ca\u5c0f\u5206\u5b50\u914d\u4f53\u590d\u5408\u7269\u7ed3\u6784\u4e0e\u76f8\u4e92\u4f5c\u7528\u7684\u4e00\u4f53\u5316\u9884\u6d4b&#xff0c;\u4e3a\u7cbe\u51c6\u89e3\u8bfb\u5206\u5b50\u95f4\u4f5c\u7528\u673a\u5236\u63d0\u4f9b\u4e86\u6838\u5fc3\u6280\u672f\u652f\u6491\u3002\u540c\u5e74&#xff0c;AlphaFold\u7cfb\u5217\u7814\u7a76\u65a9\u83b7\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956&#xff0c;\u6210\u4e3a\u4eba\u5de5\u667a\u80fd\u6280\u672f\u9996\u6b21\u83b7\u5f97\u81ea\u7136\u79d1\u5b66\u8bfa\u5956\u8ba4\u53ef\u7684\u6807\u5fd7\u6027\u4e8b\u4ef6&#xff0c;\u6b63\u5f0f\u786e\u7acb\u4e86AI for Science\u7684\u79d1\u5b66\u5408\u6cd5\u6027\u4e0e\u6838\u5fc3\u53d1\u5c55\u5730\u4f4d\u30022026\u5e74&#xff0c;AI\u6280\u672f\u4ece\u201c\u7ed3\u6784\u89e3\u6790\u201d\u8d70\u5411\u201c\u667a\u80fd\u9884\u6d4b\u4e0e\u5206\u5b50\u8bbe\u8ba1\u201d&#xff0c;AlphaFold \u51ed\u501f\u6210\u719f\u7684\u7ed3\u6784\u5efa\u6a21\u4f53\u7cfb\u3001\u6d77\u91cf\u53ef\u4fe1\u7684\u751f\u7269\u7ed3\u6784\u6570\u636e\u5e93\u4e0e\u901a\u7528\u9002\u914d\u6027&#xff0c;\u4f9d\u65e7\u662f\u5f53\u524d\u751f\u7269\u5206\u5b50AI\u8bbe\u8ba1\u9886\u57df\u4e0d\u53ef\u6216\u7f3a\u7684\u57fa\u7840\u6027\u6838\u5fc3\u5de5\u5177\u3002<\/p>\n<\/p>\n<p class=\"img-center\"><img loading=\"lazy\" decoding=\"async\" alt=\"\u56fe\u7247\" height=\"390\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/09\/20260909064914-6aa1016ad0ce9.png\" width=\"692\" \/><\/p>\n<p>\u4f9d\u6258\u9ad8\u6548\u7cbe\u51c6\u7684\u86cb\u767d\u7ed3\u6784\u9884\u6d4b\u80fd\u529b&#xff0c;AlphaFold\u5df2\u4ece\u7406\u8bba\u6280\u672f\u7a81\u7834\u843d\u5730\u81f3\u591a\u9886\u57df\u79d1\u7814\u4e0e\u4ea7\u4e1a\u573a\u666f&#xff0c;\u5728\u75be\u75c5\u673a\u5236\u7814\u7a76\u3001\u521b\u65b0\u836f\u7269\u7814\u53d1\u3001\u7279\u6b8a\u86cb\u767d\u529f\u80fd\u63a2\u7d22\u7b49\u65b9\u5411\u8bde\u751f\u4e86\u5927\u91cf\u6807\u6746\u6027\u5e94\u7528\u6848\u4f8b&#xff0c;\u76f4\u89c2\u4f53\u73b0\u4e86\u4eba\u5de5\u667a\u80fd\u8d4b\u80fd\u7ed3\u6784\u751f\u7269\u5b66\u7684\u6838\u5fc3\u4ef7\u503c\u3002\u4e0b\u9762\u5c06\u5177\u4f53\u4ecb\u7ecdAlphaFold\u7684\u5b9e\u9645\u5e94\u7528\u6848\u4f8b\u3002<\/p>\n<\/p>\n<p>\u6848\u4f8b\u4e00<\/p>\n<p>Cell | \u95eb\u6960\u56e2\u961f\u89e3\u6790STING \u4ece\u5185\u8d28\u7f51\u8f93\u51fa\u7684\u5206\u5b50\u673a\u5236<\/p>\n<p>\u9898\u76ee&#xff1a;STING signaling modulation by COPII cargo recognition<\/p>\n<p>\u6458\u8981&#xff1a;\u5e72\u6270\u7d20\u57fa\u56e0\u523a\u6fc0\u86cb\u767d&#xff08;STING&#xff09;\u7684\u6fc0\u6d3b\u4f9d\u8d56 COPII&#xff08;\u5916\u58f3\u86cb\u767d\u590d\u5408\u7269 \u2161&#xff09;\u4ecb\u5bfc\u7684\u5185\u8d28\u7f51\u8f93\u51fa&#xff0c;\u4f46\u5176\u5177\u4f53\u673a\u5236\u5c1a\u4e0d\u660e\u786e\u3002\u672c\u7814\u7a76\u9274\u5b9a\u51faEE\u03a6x\u03a6 \u57fa\u5e8f&#xff08;\u4eba\u6e90 STING \u7684 \u00b3\u00b3\u2079EEVTV\u00b3\u2074\u00b3&#xff09;\u662f\u88ab SEC24C \u8bc6\u522b\u7684\u5185\u8d28\u7f51\u8f93\u51fa\u4fe1\u53f7\u3002\u501f\u52a9 AlphaFold3 \u5f97\u5230 SEC24C \u4e0e STING \u4e8c\u805a\u4f53\u7684\u9884\u6d4b\u7ed3\u6784&#xff0c;\u8be5 EE\u03a6x\u03a6 \u57fa\u5e8f\u4f4d\u4e8e\u6b64\u524d\u7ed3\u6784\u672a\u89e3\u6790\u7684\u533a\u57df\u3002\u8be5\u57fa\u5e8f\u7a81\u53d8\u6216 SEC24C \u8d27\u7269\u7ed3\u5408\u53e3\u888b\u7a81\u53d8&#xff0c;\u5747\u4f1a\u7834\u574f STING \u7684\u8f6c\u8fd0\u4e0e\u4e0b\u6e38\u4fe1\u53f7\u3002\u672c\u7814\u7a76\u652f\u6301STING \u5be1\u805a\u5316-\u4eb2\u5408\u529b\u9608\u503c\u6a21\u578b&#xff0c;\u89e3\u91ca\u5176\u53d7\u8c03\u63a7\u7684\u5185\u8d28\u7f51\u8f93\u51fa\u673a\u5236\u3002EE\u03a6x\u03a6 \u57fa\u5e8f\u5728\u810a\u690e\u52a8\u7269 STING \u4e2d\u4fdd\u5b88&#xff0c;\u8db3\u4ee5\u4ecb\u5bfc\u5f02\u6e90\u86cb\u767d\u7684\u5185\u8d28\u7f51\u8f93\u51fa\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f&#xff0c;\u76f8\u8f83\u4e8e SEC24C \u7684\u7ecf\u5178\u8d27\u7269\u86cb\u767d&#xff0c;STING \u7684\u8be5\u8f93\u51fa\u57fa\u5e8f\u5c5e\u4e8e\u6b21\u4f18\u57fa\u5e8f&#xff0c;\u8fd9\u5bf9\u907f\u514d\u514d\u75ab\u8fc7\u5ea6\u6fc0\u6d3b\u81f3\u5173\u91cd\u8981&#xff1b;\u4eba\u5de5\u6539\u9020\u7684 \u201c\u8d85\u5f3a\u5185\u8d28\u7f51\u8f93\u51fa\u201d STING \u53ef\u7ec4\u6210\u578b\u6fc0\u6d3b&#xff0c;\u8bf1\u5bfc\u5f3a\u6548\u6297\u80bf\u7624\u514d\u75ab\u3002\u8be5\u57fa\u5e8f\u4e32\u8054\u91cd\u590d\u5e8f\u5217\u8fd8\u53ef\u7ade\u4e89\u6027\u6291\u5236\u5185\u6e90 STING \u4fe1\u53f7\u3002\u7efc\u4e0a&#xff0c;\u672c\u7814\u7a76\u89e3\u6790\u4e86 STING \u5185\u8d28\u7f51\u8f93\u51fa\u7684\u5206\u5b50\u673a\u5236&#xff0c;\u5e76\u63d0\u51fa\u8c03\u63a7 STING \u4fe1\u53f7\u7684\u5e72\u9884\u7b56\u7565\u3002<\/p>\n<\/p>\n<p class=\"img-center\"><img loading=\"lazy\" decoding=\"async\" alt=\"\u56fe\u7247\" height=\"1080\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/09\/20260909064914-6aa1016aeeb0a.png\" width=\"1080\" \/><\/p>\n<\/p>\n<p>\u4e3a\u4ec0\u4e48\u9009\u62e9AlphaFold3 &#xff1f;<\/p>\n<\/p>\n<p>AlphaFold3 \u652f\u6301\u591a\u7ec4\u5206\u751f\u7269\u5927\u5206\u5b50\u590d\u5408\u7269\u9884\u6d4b&#xff0c;\u53ef\u540c\u65f6\u5bf9\u86cb\u767d-\u86cb\u767d\u590d\u5408\u7269\u505a\u4e09\u7ef4\u5efa\u6a21&#xff0c;\u80fd\u591f\u9884\u6d4b\u4ee5\u5f80\u5b9e\u9a8c\u89e3\u6790\u4e0d\u5230\u7684\u65e0\u5e8f\u80bd\u6bb5\u5728\u7ed3\u5408\u72b6\u6001\u4e0b\u7684\u6784\u8c61&#xff0c;\u9002\u5408\u89e3\u6790 STING \u4e8c\u805a\u4f53\u4e0e SEC24C \u7684\u590d\u5408\u7269\u3002<\/p>\n<\/p>\n<p>AlphaFold3 \u9884\u6d4b\u7ed3\u679c<\/p>\n<\/p>\n<p class=\"img-center\"><img loading=\"lazy\" decoding=\"async\" alt=\"\u56fe\u7247\" height=\"748\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/09\/20260909064915-6aa1016b8d527.png\" width=\"1080\" \/><\/p>\n<p>AlphaFold3 \u5bf9\u4eba SEC24C\u2011\u4eba STING \u4e8c\u805a\u4f53\u590d\u5408\u7269\u7684\u7ed3\u6784\u9884\u6d4b<\/p>\n<\/p>\n<p class=\"img-center\"><img loading=\"lazy\" decoding=\"async\" alt=\"\u56fe\u7247\" height=\"534\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/09\/20260909064916-6aa1016c11fc9.png\" width=\"1080\" \/><\/p>\n<p>AlphaFold3 \u9884\u6d4b\u5f97\u5230\u7684 SEC24C \u4e0e STING\u3001NleA \u4e4b\u95f4\u7684\u6c28\u57fa\u9178\u76f8\u4e92\u4f5c\u7528\u4f4d\u70b9<\/p>\n<\/p>\n<p>\u6848\u4f8b\u4e8c<\/p>\n<p>The Plant Cell | \u6377\u514b\u79d1\u5b66\u9662\u5b9e\u9a8c\u690d\u7269\u7814\u7a76\u6240\u89e3\u5bc6eIF3E \u4f9d\u9760 PCI \u57df\u8c03\u63a7\u7ffb\u8bd1\u7a33\u6001\u4ecb\u5bfc\u82b1\u7c89\u7ba1\u6781\u6027\u751f\u957f<\/p>\n<p>\u9898\u76ee&#xff1a;Domain architecture of plant eukaryotic translation initiation factor 3 subunit E governs interaction with translational cis-elements to regulate pollen tube growth<\/p>\n<p>\u6458\u8981&#xff1a;eIF3E\u53ef\u901a\u8fc7\u9009\u62e9\u6027\u8bc6\u522bmRNA\u4e0e\u6838\u7cd6\u4f53\u7ec4\u88c5\u7ef4\u6301\u7ffb\u8bd1\u7a33\u6001&#xff0c;\u4f46\u5176\u7ef4\u6301\u7ffb\u8bd1\u5e73\u8861\u7684\u5206\u5b50\u673a\u5236\u5c1a\u4e0d\u660e\u786e\u3002\u672c\u7814\u7a76\u53d1\u73b0&#xff0c;eIF3E \u7684\u7ed3\u6784\u57df\u6392\u5e03\u53ca\u78f7\u9178\u5316\u4f4d\u70b9 Thr417\u3001Ser421 \u5728\u771f\u6838\u751f\u7269\u4e2d\u9ad8\u5ea6\u4fdd\u5b88&#xff1b;\u5220\u9664 PCI\u7ed3\u6784\u57df\u4f1a\u6d88\u9664\u86cb\u767d\u6838\u5b9a\u4f4d\u3001\u7834\u574f eIF3E\u2011eIF3L \u76f8\u4e92\u4f5c\u7528&#xff0c;\u5e76\u963b\u788d eIF3E \u4ece\u591a\u805a\u6838\u7cd6\u4f53\u4e0a\u89e3\u79bb\u3002\u5bf9\u70df\u8349\u82b1\u7c89\u7ba1\u5f00\u5c55 eIF3E\u2011YFP \u4eb2\u548c RNA \u514d\u75ab\u6c89\u6dc0\u6d4b\u5e8f&#xff0c;\u9274\u5b9a\u5230\u4e00\u6279\u643a\u5e26\u7f16\u7801\u533a\u987a\u5f0f\u5143\u4ef6 MC1\u2011MC3 \u7684\u9776 mRNA\u3002mRNA \u62a5\u544a\u57fa\u56e0\u5b9e\u9a8c\u8bc1\u5b9e&#xff0c;\u8fd9\u4e9b\u5143\u4ef6\u4e32\u8054\u53d1\u6325 eIF3E \u4f9d\u8d56\u6027\u7684\u7ffb\u8bd1\u6291\u5236\u4e0e\u6fc0\u6d3b\u529f\u80fd\u3002AlphaFold3 \u7ed3\u6784\u5efa\u6a21\u7ed3\u5408 FRET \u5b9e\u9a8c\u9a8c\u8bc1\u8868\u660e&#xff1a;PCI \u7ed3\u6784\u57df\u7f3a\u5931&#xff0c;\u6216\u8be5\u7ed3\u6784\u57df\u78f7\u9178\u5316\u4f4d\u70b9\u7a81\u53d8&#xff0c;\u4f1a\u524a\u5f31 eIF3E\u2011eIF3L \u4e92\u4f5c&#xff0c;\u963b\u65ad MC2 \u4ecb\u5bfc\u7684\u7ffb\u8bd1\u6fc0\u6d3b\u3002\u8fdb\u4e00\u6b65\u5b9e\u9a8c\u8bc1\u660e&#xff0c;PCI \u7ed3\u6784\u57df\u7f3a\u5931\u6216\u78f7\u9178\u4f4d\u70b9\u7a81\u53d8\u4f1a\u9020\u6210\u82b1\u7c89\u7ba1\u751f\u957f\u53ca\u819c\u7ed3\u6784\u7d0a\u4e71\u3002\u7efc\u4e0a&#xff0c;\u672c\u7814\u7a76\u8868\u660e eIF3E \u662f mRNA \u7ffb\u8bd1\u7684\u9009\u62e9\u6027\u8c03\u63a7\u56e0\u5b50&#xff0c;\u5b83\u5c06\u987a\u5f0f\u5143\u4ef6\u8bc6\u522b\u4e0e\u7ec6\u80de\u819c\u5b8c\u6574\u6027\u3001\u82b1\u7c89\u7ba1\u751f\u957f\u76f8\u8026\u5408&#xff0c;\u4fdd\u969c\u690d\u7269\u80b2\u6027\u3002<\/p>\n<\/p>\n<p class=\"img-center\"><img loading=\"lazy\" decoding=\"async\" alt=\"\u56fe\u7247\" height=\"669\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/09\/20260909064916-6aa1016c79c06.png\" width=\"1080\" \/><\/p>\n<\/p>\n<p>\u4e3a\u4ec0\u4e48\u9009\u62e9AlphaFold3 &#xff1f;<\/p>\n<\/p>\n<p>eIF3E\u2011eIF3L\/eIF3D \u7684\u76f4\u63a5\u86cb\u767d\u4e92\u4f5c\u754c\u9762\u7f3a\u4e4f\u9ad8\u5206\u8fa8\u5b9e\u9a8c\u6676\u4f53 \/ \u51b7\u51bb\u7535\u955c\u7ed3\u6784&#xff0c;\u4e0d\u6e05\u695a\u4e8c\u8005\u7ed3\u5408\u7684\u5173\u952e\u7ed3\u6784\u57fa\u7840&#xff1b;\u4f20\u7edf\u9175\u6bcd\u53cc\u6742\u4ea4\u3001FRET \u4ec5\u80fd\u8bc1\u660e\u5b58\u5728\u76f8\u4e92\u4f5c\u7528&#xff0c;\u65e0\u6cd5\u83b7\u5f97\u5206\u5b50\u5c42\u9762\u7ed3\u5408\u6a21\u5f0f\u3002\u4e3a\u9274\u5b9a\u751f\u6b96\u7ec4\u7ec7\u4e2d\u4e0e eIF3E \u76f8\u4e92\u4f5c\u7528\u7684\u86cb\u767d\u8d28&#xff0c;\u7814\u7a76\u8005\u91c7\u7528\u8ba1\u7b97\u4e0e\u5b9e\u9a8c\u76f8\u7ed3\u5408\u7684\u65b9\u6cd5\u5bf9 eIF3E \u7684\u76f8\u4e92\u4f5c\u7528\u7ec4\u8fdb\u884c\u4e86\u7814\u7a76\u3002\u4f7f\u7528 AlphaFold3\u548c ColabFold\u5bf9AteIF3E\u4e0e\u591a\u4e2aeIF3\u6838\u5fc3\u4e9a\u57fa\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u8fdb\u884c\u4e86\u7ed3\u6784\u9884\u6d4b&#xff0c;\u6a21\u62df\u5176\u76f8\u4e92\u4f5c\u7528\u3002\u5229\u7528 ipTM\u3001pTM\u3001pLDDT \u8bc4\u4ef7\u590d\u5408\u7269\u9884\u6d4b\u7f6e\u4fe1\u5ea6&#xff0c;\u4e3a\u540e\u7eed\u5b9a\u70b9\u7a81\u53d8\u3001FRET \u5b9e\u9a8c\u63d0\u4f9b\u7ed3\u6784\u5047\u8bf4\u6307\u5bfc\u3002<\/p>\n<\/p>\n<p>AlphaFold3 \u9884\u6d4b\u7ed3\u679c<\/p>\n<\/p>\n<p class=\"img-center\"><img loading=\"lazy\" decoding=\"async\" alt=\"\u56fe\u7247\" height=\"569\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/09\/20260909064916-6aa1016cd0279.png\" width=\"1080\" \/><\/p>\n<p>AlphaFold3 \u4e0e ColabFold\u751f\u6210 eIF3E \u5206\u522b\u4e0e eIF3L\u3001eIF3D \u76f8\u4e92\u4f5c\u7528\u7684\u4e8c\u7ef4\u9884\u6d4b\u7ed3\u6784\u6a21\u578b&#xff1b;PCI \u7ed3\u6784\u57df\u622a\u77ed\u540e\u7684 eIF3E \u4e0e eIF3L \u7684\u4f5c\u7528\u6a21\u578b&#xff1b;eIF3E \u4e0e\u5916\u5468\u4e9a\u57fa eIF3D \u7684\u9884\u6d4b\u6a21\u578b<\/p>\n<\/p>\n<p class=\"img-center\"><img loading=\"lazy\" decoding=\"async\" alt=\"\u56fe\u7247\" height=\"360\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/09\/20260909064917-6aa1016d2fd18.png\" width=\"1080\" \/><\/p>\n<p>\u514d\u75ab\u5171\u6c89\u6dc0-\u8d28\u8c31&#xff08;LC-MS\/MS&#xff09;\u3001\u9175\u6bcd\u53cc\u6742\u4ea4 Y2H\u3001\u53d7\u4f53\u5149\u6f02\u767d FRET \u5b9e\u9a8c\u9a8c\u8bc1 AI \u9884\u6d4b&#xff1a;eIF3E \u76f4\u63a5\u7ed3\u5408 eIF3D\u3001eIF3L&#xff0c;\u4e0d\u7ed3\u5408 eIF3A\/eIF3G&#xff1b;NSF\u3001PCI \u4e24\u4e2a\u7ed3\u6784\u57df\u5bf9\u4e8e eIF3E-eIF3L \u7684\u4f53\u5185\u4e92\u4f5c\u4e0d\u53ef\u6216\u7f3a<\/p>\n<\/p>\n<p>\u6848\u4f8b\u4e09<\/p>\n<\/p>\n<p>Cell Reports | \u7ebd\u7ea6\u5927\u5b66\u56e2\u961f\u89e3\u6790KRAS4A\u4fc3\u8fdb\u7ebf\u7c92\u4f53\u4e0a\u5df1\u7cd6\u6fc0\u91761\u7684\u5be1\u805a\u5316<\/p>\n<p>\u9898\u76ee&#xff1a;KRAS4A promotes oligomerization of hexokinase 1 on mitochondria<\/p>\n<p>\u6458\u8981&#xff1a;\u81f4\u764c KRAS \u53ef\u53d8\u526a\u63a5\u53d8\u4f53 KRAS4A \u53ef\u7ed3\u5408\u7ebf\u7c92\u4f53\u5916\u819c\u5df1\u7cd6\u6fc0\u9176 HK1 \u5e76\u4fc3\u8fdb\u7cd6\u9175\u89e3&#xff0c;\u4f46\u4f5c\u7528\u673a\u5236\u4e0d\u660e\u3002\u8be5\u7814\u7a76\u7ed3\u5408\u751f\u5316\u5b9e\u9a8c\u3001STORM \u8d85\u5206\u8fa8\u6210\u50cf\u3001\u6d3b\u7ec6\u80de\u5355\u5206\u5b50\u793a\u8e2a\u4e0e AlphaFold3 \u9884\u6d4b\u53d1\u73b0&#xff1a;\u53bb\u68d5\u6988\u9170\u5316\u3001GTP \u7ed3\u5408\u578b KRAS4A \u4ec5\u5728\u7ebf\u7c92\u4f53\u5916\u819c\u4fc3\u8fdb HK1 \u5be1\u805a&#xff0c;KRAS4B\u3001HRAS \u65e0\u6b64\u4f5c\u7528\u3002KRAS4A \u901a\u8fc7\u964d\u4f4e HK1 \u819c\u6269\u6563\u901f\u7387\u3001\u5ef6\u957f\u9a7b\u7559\u65f6\u95f4&#xff0c;\u63d0\u9ad8 HK1 \u5206\u5b50\u78b0\u649e\u6982\u7387&#xff0c;HK1 \u5be1\u805a\u7f13\u89e3\u4ea7\u7269 G\u20116\u2011P \u7684\u522b\u6784\u6291\u5236&#xff0c;\u63d0\u5347\u9176\u6d3b\u6027&#xff0c;\u9610\u91ca\u4e86\u80bf\u7624\u74e6\u6c0f\u6548\u5e94\u65b0\u8c03\u63a7\u673a\u5236\u3002AlphaFold3 \u6a21\u578b\u63d0\u793a KRAS4A \u7ed3\u5408 HK1 \u4e8c\u805a\u4f53 N \u7aef\u6fc0\u9176\u57df&#xff0c;\u4e8c\u8005\u819c\u951a\u5b9a\u5e8f\u5217\u671d\u5411\u7ebf\u7c92\u4f53\u5916\u819c&#xff1b;\u8be5 AI \u7ed3\u679c\u4ec5\u4e3a\u7ed3\u6784\u5047\u8bf4&#xff0c;\u5c1a\u65e0\u6676\u4f53 \/ \u51b7\u51bb\u7535\u955c\u5b9e\u9a8c\u7ed3\u6784\u76f4\u63a5\u9a8c\u8bc1&#xff0c;\u7814\u7a76\u672a\u76f4\u63a5\u68c0\u6d4b\u4e0b\u6e38\u5b8c\u6574\u4ee3\u8c22\u6d41\u3002<\/p>\n<\/p>\n<p class=\"img-center\"><img loading=\"lazy\" decoding=\"async\" alt=\"\u56fe\u7247\" height=\"1080\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/09\/20260909064917-6aa1016d67165.png\" width=\"1080\" \/><\/p>\n<\/p>\n<p>\u4e3a\u4ec0\u4e48\u9009\u62e9AlphaFold3 &#xff1f;<\/p>\n<\/p>\n<p>\u751f\u5316\u8bc1\u660e KRAS4A \u7ed3\u5408 HK1 \u7684 N\u7aef\u6fc0\u9176\u57df&#xff0c;\u4f46\u7f3a\u5c11\u9ad8\u5206\u8fa8\u5b9e\u9a8c\u7ed3\u6784&#xff1b;\u5229\u7528 AlphaFold3 \u751f\u6210 HK1-KRAS4A \u590d\u5408\u7269\u6a21\u578b&#xff0c;\u89e3\u91ca\u4e8c\u8005\u76f8\u4e92\u4f5c\u7528\u6a21\u5f0f\u4e0e\u819c\u53d6\u5411\u3002<\/p>\n<\/p>\n<p>AlphaFold3 \u9884\u6d4b\u7ed3\u679c<\/p>\n<\/p>\n<p>\u9884\u6d4b KRAS4A \u7684 Switch-I\/II \u6548\u5e94\u533a\u7ed3\u5408 HK1 \u4e8c\u805a\u4f53\u7684 N-\u7aef\u6fc0\u9176\u57df&#xff1b;HK1 \u7ebf\u7c92\u4f53\u7ed3\u5408\u80bd\u6bb5\u4e0e KRAS4A \u9ad8\u53d8\u533a HVR \u671d\u5411\u540c\u4e00\u4fa7&#xff0c;\u652f\u6301\u4e8c\u8005\u5171\u540c\u951a\u5b9a\u7ebf\u7c92\u4f53\u5916\u819c\u3002\u8be5\u8ba1\u7b97\u6a21\u578b\u4e0e\u751f\u5316\u7ed3\u679c\u5b8c\u5168\u543b\u5408\u3002<\/p>\n<\/p>\n<p class=\"img-center\"><img loading=\"lazy\" decoding=\"async\" alt=\"\u56fe\u7247\" height=\"293\" src=\"https:\/\/www.wsisp.com\/helps\/wp-content\/uploads\/2026\/09\/20260909064917-6aa1016ddbb43.png\" width=\"1080\" \/><\/p>\n<p>AlphaFold3 \u9884\u6d4bHK1-KRAS4A\u590d\u5408\u7269\u5728 OMM \u4e0a\u7684\u7ed3\u6784<\/p>\n<\/p>\n<p>\u7efc\u4e0a&#xff0c;AlphaFold \u80fd\u591f\u4e3a\u9776\u70b9\u7ed3\u6784\u89e3\u6790\u3001\u7ed3\u5408\u6a21\u5f0f\u9884\u5224\u3001\u5206\u5b50\u4e92\u4f5c\u673a\u5236\u6316\u6398\u63d0\u4f9b\u5f3a\u6709\u529b\u7684\u5148\u9a8c\u4fe1\u606f\u3002\u4f46\u7ed3\u6784\u9884\u6d4b\u53ea\u662f\u8d77\u70b9&#xff0c;\u4ece\u83b7\u5f97\u9ad8\u8d28\u91cf\u590d\u5408\u7269\u6a21\u578b&#xff0c;\u5230\u9762\u5411\u7279\u5b9a\u9776\u70b9\u5f00\u5c55\u5b9a\u5411 AI \u5206\u5b50\u8bbe\u8ba1\u3001\u5019\u9009\u5206\u5b50\u7b5b\u9009\u4e0e\u865a\u62df\u9a8c\u8bc1&#xff0c;\u5b8c\u6574\u843d\u5730\u94fe\u6761\u4ecd\u9700\u8981\u7ed3\u6784\u5efa\u6a21\u3001\u5206\u5b50\u751f\u6210\u3001\u5bf9\u63a5\u7b5b\u9009\u3001\u7ed3\u679c\u6821\u9a8c\u7b49\u591a\u6a21\u5757\u5de5\u5177\u534f\u540c\u3002<\/p>\n<\/p>\n<p>\u53c2\u8003\u6587\u732e<\/p>\n<\/p>\n<p>[1]Lyu H, Xing C, Huai W, et al. STING signaling modulation by COPII cargo recognition[J]. Cell, 2026, 189(11): 2588\u20112604.e1\u2011e6. [https:\/\/doi.org\/10.1016\/j.cell.2026.02.029](https:\/\/doi.org\/10.1016\/j.cell.2026.02.029).<\/p>\n<p>[2]Kumar V, Merret R, Carpentier M C, et al. Domain architecture of plant eukaryotic translation initiation factor 3 subunit E governs interaction with translational ciselements to regulate pollen tube growth[J]. The Plant Cell, 2026, 38(2): koag005. https:\/\/doi.org\/10.1093\/plcell\/koag005.<\/p>\n<p>[3]NuevoTapioles C, Qin Z, Bazley A, et al. KRAS4A promotes oligomerization of hexokinase 1 on mitochondria[J]. 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