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mg\u7c89\u672b\u5f62\u5f0f\u4ee5\u53caC7641-2s\u76842 mg\u300110 mM DMSO\u9884\u914d\u5f62\u5f0f\u3002\u4e24\u79cd\u5f62\u5f0f\u4e3b\u8981\u5f71\u54cd\u5b9e\u9a8c\u5ba4\u7684\u914d\u6db2\u6d41\u7a0b\u548c\u4f7f\u7528\u4fbf\u5229\u6027&#xff0c;\u5b9e\u9645\u5904\u7406\u6d53\u5ea6\u4ecd\u7136\u9700\u8981\u6839\u636e\u76ee\u6807\u7ec6\u80de\u3001\u57f9\u517b\u4f53\u7cfb\u548c\u7814\u7a76\u7ec8\u70b9\u8fdb\u884c\u5242\u91cf-\u65f6\u95f4\u9884\u5b9e\u9a8c\u3002<\/p>\n<h3>\u4e5d\u3001\u603b\u7ed3<\/h3>\n<p>Wnt-C59\u901a\u8fc7PORCN\u5e72\u9884Wnt\u914d\u4f53\u8102\u9170\u5316\u4e0e\u5206\u6ccc&#xff0c;\u56e0\u6b64\u6700\u9002\u5408\u7528\u4e8e\u914d\u4f53\u4f9d\u8d56\u578bWnt\u673a\u5236\u7814\u7a76\u3002\u7406\u89e3\u8fd9\u4e00\u4f5c\u7528\u4f4d\u7f6e&#xff0c;\u662f\u6b63\u786e\u89e3\u91caWnt-C59\u5b9e\u9a8c\u7ed3\u679c\u7684\u524d\u63d0\u3002<\/p>\n<p>\u5982\u679c\u6a21\u578b\u4e2dWnt\u4fe1\u53f7\u6765\u81ea\u81ea\u5206\u6ccc\u3001\u65c1\u5206\u6ccc\u6216\u6b63\u5e38\u5916\u6e90\u914d\u4f53\u8f93\u5165&#xff0c;PORCN\u6291\u5236\u6709\u673a\u4f1a\u663e\u8457\u964d\u4f4e\u4fe1\u53f7&#xff1b;\u5982\u679c\u4e0b\u6e38\u5df2\u7ecf\u56e0\u4e3aAPC\u3001CTNNB1\u7b49\u5f02\u5e38\u800c\u6301\u7eed\u6d3b\u8dc3&#xff0c;\u5219Wnt-C59\u53ef\u80fd\u4ea7\u751f\u6709\u9650\u5f71\u54cd\u3002\u7ed3\u5408CHIR99021\u3001Wnt3a\u3001TopFlash\u3001AXIN2\u3001\u03b2-catenin\u5b9a\u4f4d\u548c\u529f\u80fd\u8868\u578b&#xff0c;\u53ef\u4ee5\u66f4\u52a0\u5b8c\u6574\u5730\u5224\u65ad\u4e00\u4e2a\u6a21\u578b\u4e2d\u7684Wnt\u4fe1\u53f7\u7a76\u7adf\u6765\u81ea\u54ea\u91cc\u3002<\/p>\n<p>\u5bf9\u4e8e\u7c7b\u5668\u5b98\u3001\u80bf\u7624\u6a21\u578b\u548c\u5e72\u7ec6\u80de\u5206\u5316\u800c\u8a00&#xff0c;Wnt-C59\u771f\u6b63\u7684\u7814\u7a76\u4ef7\u503c\u4e0d\u662f\u201c\u628aWnt\u5173\u95ed\u201d&#xff0c;\u800c\u662f\u5e2e\u52a9\u7814\u7a76\u4eba\u5458\u628aWnt\u901a\u8def\u62c6\u6210\u4e0d\u540c\u8282\u70b9&#xff0c;\u5e76\u901a\u8fc7\u5b9e\u9a8c\u56de\u7b54\u66f4\u52a0\u5177\u4f53\u7684\u673a\u5236\u95ee\u9898\u3002<\/p>\n<h3>\u53c2\u8003\u8d44\u6599<\/h3>\n<li>Chen B, Dodge ME, Tang W, et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature Chemical Biology. 2009;5(2):100\u2013107.<\/li>\n<li>Proffitt KD, Madan B, Ke Z, et al. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Research. 2013;73(2):502\u2013507.<\/li>\n<li>Dai Chen et al. N-(HETERO)ARYL, 2-(HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS Wnt SIGNALING MODULATORS. 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